Defensins have long been considered as merely antimicrobial peptides. Throughout the
years, more immune-related functions have been discovered for both the α-defensin and β …

Following considerable research efforts on antimicrobial effects by cationic and amphiphilic
peptides during the last couple of decades, increasing focus has recently been placed on …

Defensins are a class of host defence peptides (HDPs) that often harbour antimicrobial and
anticancer activities, making them attractive candidates as novel therapeutics. In comparison …

Defensins form an integral part of the cationic host defence peptide (HDP) family, a key
component of innate immunity. Apart from their antimicrobial and immunomodulatory …

Background Plant defensins have a hallmark γ-core motif (GXCX3-9C) that is related to their
antimicrobial properties. The aim of this work was to design synthetic peptides based on the …

Diabetic foot ulcers (DFU) are one of the most serious and devastating complications of
diabetes and account for a significant decrease in quality of life and costly healthcare …

Anticancer lipopeptides (ACLPs) are considered promising alternatives to combat resistant
cancer cells, but the influence of peptide conformational propensity alone on their selectivity …

Available treatments for invasive fungal infections have limitations, including toxicity and the
emergence of resistant strains. Therefore, there is an urgent need for alternative solutions …

The tumor suppressor protein p53 is inactive in a large number of cancers, including some
forms of sarcoma, breast cancer, and leukemia, due to overexpression of its intrinsic …

Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by the
absence of commonly targeted receptors. Unspecific chemotherapy is currently the main …