There is increasing evidence for the involvement of mitochondrial dysfunction and oxidative
stress in the pathogenesis of many of the major neurodegenerative and neuroinflammatory …

Glial fibrillary acidic protein (GFAP), a type III intermediate filament, is a marker of mature
astrocytes. The expression of GFAP gene is regulated by many transcription factors (TFs) …

The neural mechanisms underlying the development and maintenance of chronic
neuropathic pain remain unclear. Evidence from human investigations suggests that …

Chemotherapy-induced neuropathic pain (CINP) is one of the most severe side effects of
anticancer agents, such as platinum-and taxanes-derived drugs (oxaliplatin, cisplatin …

The Janus-kinase (JAK) and signal transducer activator of transcription (STAT) signalling
pathways regulate gene expression and control various factors involved in normal …

Abstract Background Traditional Chinese medicine (TCM) prescriptions have multiple
bioactive properties.“Gui Zhi–Shao Yao” herb pair is widely used to treat chronic pain (CP) …

The transmission of noxious stimuli from peripheral receptors to the cortex involves multiple
central ascending pathways. While projections to areas in the brainstem and diencephalon …

Paclitaxel-induced neuropathic pain (PINP) is a dose-limiting side effect and is refractory to
widely used analgesic drugs. Previous studies have demonstrated a protective role of …

Painful peripheral neuropathy is a dose-limiting side effect of cisplatin treatment. Using a
murine model of cisplatin-induced hyperalgesia, we determined whether a PPARg synthetic …

Chronic pain is a common cause of disability worldwide and remains a global health and
socio‐economic challenge. Current analgesics are either ineffective in a significant …