Gliomas are the most frequent type of tumor in the central nervous system, which exhibit
properties that make their treatment difficult, such as cellular infiltration, heterogeneity, and …

Pur-alpha is a ubiquitous multifunctional protein that is strongly conserved throughout
evolution, binds to both DNA and RNA and functions in the initiation of DNA replication …

Excessive copper intake can lead to neurotoxicity, but there is a lack of comprehensive
understanding on the potential impact of copper exposure especially at a low-dose on brain …

Synovial hyperplasia is the main cause of chronic rheumatoid arthritis (RA), but the
mechanism of synovial hyperplasia is still unclear. Etodolac (ETD) is a selective COX-2 …

Background and objectives: Non-aggregated protamine impregnated poly (lactide-co-
glycolide) nanoparticles of cisplatin (Pt-PLGA NPs) were synthesized to augment brain …

Esophageal squamous cell carcinoma (ESCC) is one of the most lethal gastrointestinal
malignancies due to its characteristics of local invasion and distant metastasis. Purine …

Acute myelogenous leukemia (AML) is an aggressive hematologic cancer characterized by
infiltration of proliferative, clonal, abnormally differentiated cells of myeloid lineage in the …

Abstract (1R, 2R-diaminocyclohexane)(dihydropyrophosphato) platinum (II), also
abbreviated as RRD2, belongs to a class of potent antitumor platinum cytostatics called …

One of the promising new antitumor platinum complexes is a large-ring chelate complex
[PtCl2 (cis-1, 4-DACH)](DACH= diaminocyclohexane)(kiteplatin). Recently, new platinum (II) …

富含嘌呤元件结合蛋白α (purine-rich element binding protein alpha, PURα)
基因编码富含嘌呤的DNA 和RNA 结合蛋白. PURα 在进化过程中高度保守. PURα …