Multiple system atrophy: pathology, pathogenesis, and path forward
A Ndayisaba, GM Halliday… - Annual Review of …, 2024 - annualreviews.org
Multiple system atrophy (MSA) is a fatal neurodegenerative disease characterized by
autonomic failure and motor impairment. The hallmark pathologic finding in MSA is …
autonomic failure and motor impairment. The hallmark pathologic finding in MSA is …
Intercellular transmission of alpha-synuclein
S Wu, RW Schekman - Frontiers in Molecular Neuroscience, 2024 - frontiersin.org
An emerging theme in Parkinson's disease (PD) is the propagation of α-synuclein pathology
as the disease progresses. Research involving the injection of preformed α-synuclein fibrils …
as the disease progresses. Research involving the injection of preformed α-synuclein fibrils …
Biomarker‐Based Approach to α‐Synucleinopathies: Lessons from Neuropathology
GG Kovacs, LT Grinberg, G Halliday… - Movement …, 2024 - Wiley Online Library
Recently, proposals have attempted to reclassify Lewy body diseases in vivo by merging the
long-established clinicopathological entities of Parkinson's disease (PD), Parkinson's …
long-established clinicopathological entities of Parkinson's disease (PD), Parkinson's …
High-visual-resolution colorimetric immunoassay with attomolar sensitivity using kinetically controlled growth of Ag in AuAg nanocages and poly-enzyme-boosted …
Colorimetric enzyme-linked immunosorbent assays (CELISAs) have long been used for
protein biomarker detection in diagnostics. Unfortunately, as confined by the monochromatic …
protein biomarker detection in diagnostics. Unfortunately, as confined by the monochromatic …
The amplification of alpha‐synuclein amyloid fibrils is suppressed under fully quiescent conditions
A Farzadfard, TO Mason, A Kunka… - Angewandte …, 2024 - Wiley Online Library
Seed amplification assays (SAAs) are a promising avenue for the early diagnosis of
neurodegenerative diseases. However, when amplifying fibrils from patient‐derived …
neurodegenerative diseases. However, when amplifying fibrils from patient‐derived …
Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope
We present a novel, low-cost, portable smartphone-based fluorescence microscope capable
of directly detecting single molecules without signal amplification. The setup leverages the …
of directly detecting single molecules without signal amplification. The setup leverages the …
The secondary nucleation of alpha-synuclein amyloid fibrils is suppressed under fully quiescent conditions
A Farzadfard, TO Mason, A Kunka… - 2024 - chemrxiv.org
Seed amplification assays (SAAs) are a promising avenue for the early diagnosis of
neurodegenerative diseases However, when amplifying fibrils from patient-derived samples …
neurodegenerative diseases However, when amplifying fibrils from patient-derived samples …
Combining alpha-synuclein PET and seeded-amplification to improve diagnostic accuracy of Multiple System Atrophy
V Khurana, D Rodriguez, B Changizi, C Sandiego… - 2024 - researchsquare.com
Biomarkers that facilitate early detection and track disease progression are an enormous
unmet need in neurodegenerative diseases and their clinical trials. Accurate diagnosis in …
unmet need in neurodegenerative diseases and their clinical trials. Accurate diagnosis in …
New Assay Detects Abnormal Proteins in Parkinson's Disease and Spinal Muscular Atrophy
G Shaw - Neurology Today, 2024 - journals.lww.com
A new “digital” seed amplification assay detects and quantifies single alpha-synuclein (α-
syn) aggregates—the seeding proteins for Parkinson's disease (PD) and other …
syn) aggregates—the seeding proteins for Parkinson's disease (PD) and other …