Peptide design principles for antimicrobial applications

MDT Torres, S Sothiselvam, TK Lu… - Journal of molecular …, 2019 - Elsevier
The increased incidence of bacterial resistance to available antibiotics represents a major
global health problem and highlights the need for novel anti-infective therapies …

Synthetic biology and computer-based frameworks for antimicrobial peptide discovery

MDT Torres, J Cao, OL Franco, TK Lu… - ACS …, 2021 - ACS Publications
Antibiotic resistance is one of the greatest challenges of our time. This global health problem
originated from a paucity of truly effective antibiotic classes and an increased incidence of …

Reprogramming biological peptides to combat infectious diseases

MDT Torres, C de la Fuente-Nunez - Chemical Communications, 2019 - pubs.rsc.org
With the rapid spread of resistance among parasites and bacterial pathogens, antibiotic-
resistant infections have drawn much attention worldwide. Consequently, there is an urgent …

Beauty and the beast: host microRNA-155 versus SARS-CoV-2

KI Papadopoulos, A Papadopoulou, TC Aw - Human Cell, 2023 - Springer
Severe acute respiratory coronavirus 2 (SARS-CoV-2) infection in the young and healthy
usually results in an asymptomatic or mild viral syndrome, possibly through an erythropoietin …

[HTML][HTML] COVID-19 and syndemic challenges in 'Battling the Big Three': HIV, TB and malaria

TP Velavan, CG Meyer, M Esen, PG Kremsner… - International Journal of …, 2021 - Elsevier
Indirect effects of the COVID-19 pandemic have the potential to seriously undermine the
health system in sub-Saharan Africa with an increase in the incidences of malaria …

Natural and redesigned wasp venom peptides with selective antitumoral activity

MDT Torres, GP Andrade, RH Sato… - Beilstein Journal of …, 2018 - beilstein-journals.org
About 1 in 8 US women (≈ 12%) will develop invasive breast cancer over the course of their
lifetime. Surgery, chemotherapy, radiotherapy, and hormone manipulation constitute the …

Evolutionary trilogy of malaria, angiotensin II and hypertension: deeper insights and the way forward

A De, A Tiwari, V Pande, A Sinha - Journal of Human Hypertension, 2022 - nature.com
Despite clinical and pathological distinctions between malaria and hypertension,
accumulated epidemiological and evolutionary evidence indicate the need of deeper …

The antiplasmodial and antitrypanosomal activities of novel piperazine derivatives of 3-azabicyclo [3.2. 2] nonanes

NUA Mohsin, W Seebacher, J Faist… - Monatshefte für Chemie …, 2018 - Springer
Some new piperazine derivatives of antiprotozoal active 3-azabicyclo [3.2. 2] nonanes were
prepared. Verification of the structures of the new compounds was done by one-and two …

Synthesis of new pyrido-benzodiazepine salts and their antimicrobial activities

W Seebacher, F Belaj, J Faist, R Saf, F Bucar… - Monatshefte für Chemie …, 2017 - Springer
Recently, we reported the antiprotozoal activity of tetrahydropyridylidene ammonium salts.
We inserted this motif into a fused ring system, a pyrido-benzodiazepine. The synthesis …