Proteins carry out a wide variety of catalytic, regulatory, signalling and structural functions in
living systems. Following their assembly on ribosomes and throughout their lifetimes, most …

Protein semisynthesis—defined herein as the assembly of a protein from a combination of
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …

Cyclic peptides have been attracting a lot of attention in recent decades, especially in the
area of drug discovery, as more and more naturally occurring cyclic peptides with diverse …

Contemporary chemical protein synthesis has been dramatically advanced over the past few
decades, which has enabled chemists to reach the landscape of synthetic …

D‐peptide ligands can be screened for therapeutic potency and enzymatic stability using
synthetic mirror‐image proteins (D‐proteins), but efficient acquisition of these D‐proteins …

Conspectus Synthetic proteins are expected to go beyond the boundary of recombinant
DNA expression systems by being flexibly installed with site-specific natural or unnatural …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

Total chemical protein synthesis provides access to entire D‐protein enantiomers enabling
unique applications in molecular biology, structural biology, and bioactive compound …

Disulfide-rich proteins are useful as drugs or tool molecules in biomedical studies, but their
synthesis is complicated by the difficulties associated with their folding. Here, we describe a …

Chemical synthesis of proteins with aggregable or colloidal peptide segments presents a
formidable task, as such peptides prove to be difficult for both solid-phase peptide synthesis …