Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone
homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been …

1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

Hypercalcemia occurs in up to 4% of the population in association with malignancy, primary
hyperparathyroidism, ingestion of excessive calcium and/or vitamin D, ectopic production of …

Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR). It
plays a main role in the calcium homeostasis and metabolism. In addition, vitamin D display …

Significant controversy has emerged over the last decade concerning the effects of vitamin D
on skeletal and nonskeletal tissues. The demonstration that the vitamin D receptor is …

Immunomodulatory responses to the active form of vitamin D (1, 25-dihydroxyvitamin D, 1,
25D) have been recognized for many years, but it is only in the last 5 years that the potential …

Nonclassic actions of vitamin D were first recognized 30 years ago when receptors for active
1, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3) were detected in various neoplastic cells lines …

New knowledge of the biological and clinical importance of the steroid hormone 1α, 25-
dihydroxyvitamin D 3 [1α, 25 (OH) 2 D 3] and its receptor, the vitamin D receptor (VDR), has …

The mitochondrial enzyme 25-hydroxyvitamin D3-1α-hydroxylase (1α-hydroxylase) plays an
important role in calcium homeostasis by catalyzing synthesis of the active form of vitamin D …

The discovery of the vitamin D endocrine system and a receptor for the hormonal form, 1α,
25-dihydroxyvitamin D3, has brought a new understanding of the relationship between …