Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Neuroinflammation and neurodegeneration often result from the aberrant deposition of
aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate …

Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has
high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic …

As a result of ischemia or hemorrhage, blood supply to neurons is disrupted which
subsequently promotes a cascade of pathophysiological responses resulting in cell loss …

Background Inflammatory response has been recognized as a pivotal pathophysiological
process during cerebral ischemic stroke. NLRP3 inflammasome, involved in the regulation …

Profound and debilitating fatigue is the most common complaint reported among individuals
with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 …

Background Innate immunity can facilitate early brain injury (EBI) following subarachnoid
hemorrhage (SAH). Numerous studies suggest that pyroptosis could exacerbate …

Activation of the NOD-like receptor protein (NLRP3)-inflammasome has been postulated to
mediate inflammatory responses to brain damage during ischemic/reperfusion (I/R) injury …

Traumatic brain injury (TBI) and spinal cord injury (SCI) are pathological events that lead to
neuropathological conditions which have in consequence the initiation of pro‐inflammatory …

Background Ischemic stroke is the main cause of disability worldwide, leading to a serious
socioeconomic burden. Ferroptosis is a non-apoptotic form of programmed cell death and is …