[HTML][HTML] Understanding MAPK signaling pathways in apoptosis
J Yue, JM López - International journal of molecular sciences, 2020 - mdpi.com
MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological
processes through multiple cellular mechanisms. In most of these processes, such as …
processes through multiple cellular mechanisms. In most of these processes, such as …
[HTML][HTML] The membrane surface as a platform that organizes cellular and biochemical processes
Membranes are essential for life. They act as semi-permeable boundaries that define cells
and organelles. In addition, their surfaces actively participate in biochemical reaction …
and organelles. In addition, their surfaces actively participate in biochemical reaction …
T cell circuits that sense antigen density with an ultrasensitive threshold
Overexpressed tumor-associated antigens [for example, epidermal growth factor receptor
(EGFR) and human epidermal growth factor receptor 2 (HER2)] are attractive targets for …
(EGFR) and human epidermal growth factor receptor 2 (HER2)] are attractive targets for …
[图书][B] Stochastic processes in cell biology
PC Bressloff - 2014 - Springer
One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …
components of a living cell operate in a highly noisy environment. What are the specific …
Synthetic multistability in mammalian cells
R Zhu, JM del Rio-Salgado, J Garcia-Ojalvo… - Science, 2022 - science.org
In multicellular organisms, gene regulatory circuits generate thousands of molecularly
distinct, mitotically heritable states through the property of multistability. Designing synthetic …
distinct, mitotically heritable states through the property of multistability. Designing synthetic …
[HTML][HTML] Programmable protein circuit design
Z Chen, MB Elowitz - Cell, 2021 - cell.com
A fundamental challenge in synthetic biology is to create molecular circuits that can program
complex cellular functions. Because proteins can bind, cleave, and chemically modify one …
complex cellular functions. Because proteins can bind, cleave, and chemically modify one …
Engineered dCas9 with reduced toxicity in bacteria: implications for genetic circuit design
Large synthetic genetic circuits require the simultaneous expression of many regulators.
Deactivated Cas9 (dCas9) can serve as a repressor by having a small guide RNA (sgRNA) …
Deactivated Cas9 (dCas9) can serve as a repressor by having a small guide RNA (sgRNA) …
Design principles of 3D epigenetic memory systems
Cells remember their identities, in part, by using epigenetic marks—chemical modifications
placed along the genome. How can mark patterns remain stable over cell generations …
placed along the genome. How can mark patterns remain stable over cell generations …
Complex signal processing in synthetic gene circuits using cooperative regulatory assemblies
Eukaryotic genes are regulated by multivalent transcription factor complexes. Through
cooperative self-assembly, these complexes perform nonlinear regulatory operations …
cooperative self-assembly, these complexes perform nonlinear regulatory operations …
[HTML][HTML] Size limits the sensitivity of kinetic schemes
JA Owen, JM Horowitz - Nature Communications, 2023 - nature.com
Living things benefit from exquisite molecular sensitivity in many of their key processes,
including DNA replication, transcription and translation, chemical sensing, and …
including DNA replication, transcription and translation, chemical sensing, and …