Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides
produced by interrupted translation. Central players in RQC are the human ribosome-and …

Ribosomes that become stalled on truncated or damaged mRNAs during protein synthesis
must be rescued for the cell to survive. Bacteria have evolved a diverse array of rescue …

Tight coupling of transcription and translation is considered a defining feature of bacterial
gene expression,. The pioneering ribosome can both physically associate and kinetically …

New antibiotics are urgently needed to address the mounting resistance challenge. In early
drug discovery, one of the bottlenecks is the elucidation of targets and mechanisms. To …

Bacterial ribosome rescue pathways that remove ribosomes stalled on mRNAs during
translation have been proposed as novel antibiotic targets because they are essential in …

During translation, messenger RNAs (mRNAs) are decoded by ribosomes which can stall for
various reasons. These include chemical damage, codon composition, starvation, or …

Escherichia coli has multiple pathways to release nonproductive ribosome complexes
stalled at the 3′ end of nonstop mRNA: tmRNA (SsrA RNA)‐mediated trans‐translation and …

Despite having a highly reduced genome, Chlamydia trachomatis undergoes a complex
developmental cycle in which the bacteria differentiate between the following two …

In bacterial cells we find a variety of interacting macromolecules, among them RNAs and
proteins. Not only small regulatory RNAs (sRNAs), but also small proteins have been …

Stalled ribosomes are rescued by pathways that recycle the ribosome and target the nascent
polypeptide for degradation. In E. coli, these pathways are triggered by ribosome collisions …