Cytokines and their receptors have a vital function in regulating various processes such as
immune function, inflammation, haematopoiesis, cell growth and differentiation. The …

Hematopoietic stem and progenitor cells reside within the bone marrow (BM)
microenvironment. By a well-balanced interplay between self-renewal and differentiation …

Adipose tissue is a major source of mesenchymal stem cells (MSCs), which possess a
variety of properties that make them ideal candidates for regenerative and …

The study of myelodysplastic syndromes (MDS) in murine models has now indicated the
possible involvement of the bone marrow microenvironment in the generation of dysplastic …

Mutations in cardiotrophin-like cytokine factor (CLCF1) and the related cytokine to which it
binds, cytokine receptor-like factor 1 (CRLF1), are associated with Crisponi/cold induced …

Therapy-related myeloid neoplasms (t-MN) following treatment with alkylating agents are
characterized by a del (5q), complex karyotypes, alterations of TP53, and a dismal …

The plastic-adherent, fibroblast-like, clonogenic cells found in the human body now defined
as multipotent “Mesenchymal Stromal Cells”(MSCs) hold immense potential for cell-based …

Background Myelodysplastic syndrome (MDS) is known to arise through the pathogenic
bone marrow mesenchymal stem cells (MSC) by interacting with hematopoietic stem cells …

Iron overload is a significant feature of myelodysplastic syndromes (MDS) patients due to
ineffective hematopoiesis and transfusion dependence. Excess iron results in organ …

Mesenchymal stromal cells (MSCs) are a subset of heterogeneous, non-hematopoietic
fibroblast-like cells which play important roles in tissue repair, inflammation, and immune …