Anti-trypanosomatid drug discovery: progress and challenges

M De Rycker, S Wyllie, D Horn, KD Read… - Nature Reviews …, 2023 - nature.com
Leishmaniasis (visceral and cutaneous), Chagas disease and human African
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …

Worldwide control and management of Chagas disease in a new era of globalization: a close look at congenital Trypanosoma cruzi infection

A Abras, C Ballart, A Fernández-Arévalo… - Clinical microbiology …, 2022 - Am Soc Microbiol
Population movements have turned Chagas disease (CD) into a global public health
problem. Despite the successful implementation of subregional initiatives to control vectorial …

Winner–loser species replacements in human-modified landscapes

BKC Filgueiras, CA Peres, FPL Melo, IR Leal… - Trends in Ecology & …, 2021 - cell.com
Community assembly arguably drives the provision of ecosystem services because they
critically depend on which and how species coexist. We examine conspicuous cases …

[HTML][HTML] Human-mediated impacts on biodiversity and the consequences for zoonotic disease spillover

CK Glidden, N Nova, MP Kain, KM Lagerstrom… - Current Biology, 2021 - cell.com
Human-mediated changes to natural ecosystems have consequences for both ecosystem
and human health. Historically, efforts to preserve or restore 'biodiversity'can seem to be in …

Chagas disease

AS de Sousa, D Vermeij, AN Ramos, AO Luquetti - The Lancet, 2024 - thelancet.com
Chagas disease persists as a global public health problem due to the high morbidity and
mortality burden. Despite the possibility of a cure and advances in transmission control …

[HTML][HTML] Chagas disease control-surveillance in the Americas: the multinational initiatives and the practical impossibility of interrupting vector-borne Trypanosoma …

AR de Arias, C Monroy, F Guhl… - Memórias do Instituto …, 2022 - SciELO Brasil
Chagas disease (CD) still imposes a heavy burden on most Latin American countries.
Vector-borne and mother-to-child transmission cause several thousand new infections per …

What do you need to know before studying Chagas disease? A beginner's guide

JA De Fuentes-Vicente, NG Santos-Hernández… - Tropical Medicine and …, 2023 - mdpi.com
Chagas disease is one of the most important tropical infections in the world and mainly
affects poor people. The causative agent is the hemoflagellate protozoan Trypanosoma …

Host diversity and origin of zoonoses: The ancient and the new

J Recht, VJ Schuenemann, MR Sánchez-Villagra - Animals, 2020 - mdpi.com
Simple Summary There is a wide variety of diseases caused by bacteria, viruses, and
parasites that are transmitted to humans by different routes from other animals. These …

Poverty, migration, and Chagas disease

F Guhl, JD Ramírez - Current Tropical Medicine Reports, 2021 - Springer
Abstract Purpose of Review Chagas disease is among the most serious problems for public
health in Latin America. Although the causative agent Trypanosoma cruzi and its triatomine …

Landmarks of the Knowledge and Trypanosoma cruzi Biology in the Wild Environment

AM Jansen, SCC Xavier, ALR Roque - Frontiers in Cellular and …, 2020 - frontiersin.org
Trypanosomatids are ancient parasitic eukaryotes that still maintain prokaryotic
characteristics. Trypanosoma cruzi, a primarily wild mammal parasite, infected humans …