Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Astrocytes react to CNS injury by building a dense wall of filamentous processes around the
lesion. Stromal cells quickly take up residence in the lesion core and synthesize connective …

After injury to the adult central nervous system (CNS), injured axons cannot regenerate past
the lesion. In this review, we present evidence that this is due to the formation of a glial scar …

Fibrotic scar tissue limits central nervous system regeneration in adult mammals. The extent
of fibrotic tissue generation and distribution of stromal cells across different lesions in the …

During restricted time windows of postnatal life, called critical periods, neural circuits are
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …

After central nervous system (CNS) injury, inhibitory factors in the lesion scar and poor axon
growth potential prevent axon regeneration. Microtubule stabilization reduces scarring and …

Although spontaneous regeneration of lesioned fibres is limited in the adult central nervous
system, many people that suffer from incomplete spinal cord injuries show significant …

It is self-evident that the adult mammalian brain and spinal cord do not regenerate after
injury, but recent discoveries have forced a reconsideration of this accepted principle …

Vascular endothelial growth factor (VEGF) is a hypoxia-inducible angiogenic peptide with
recently identified neurotrophic effects. Because some neurotrophic factors can protect …