Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding
hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid …

Acute inflammation or resolved inflammation is an adaptive host defense mechanism and is
self-limiting, which returns the body to a state of homeostasis. However, unresolved …

Motivation: Gene expression class comparison studies may identify hundreds or thousands
of genes as differentially expressed (DE) between sample groups. Gaining biological insight …

Metabolic syndrome is estimated to affect more than one in five adults, and its prevalence is
growing in the adult and pediatric populations. The most widely recognized metabolic risk …

Peroxisome proliferator-activated receptor-delta (PPAR-δ), one of three members of the
PPAR group in the nuclear receptor superfamily, is a ligand-activated transcription factor …

Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) show indisputable
promise as chemopreventive agents. Possible targets include cancers of the colon, stomach …

Nonsteroidal antiinflammatory drugs (NSAIDs) appear to reduce the risk of developing
cancer. One mechanism through which NSAIDs act to reduce carcinogenesis is to inhibit the …

12/15-Lipoxygenases (12/15-LOX) are members of the LOX family, which are expressed in
mammals by monocytes and macrophages following induction by the T helper type 2 …

Lipoxygenases (LOXs) catalyze the stereo-specific peroxidation of polyunsaturated fatty
acids (PUFAs) to their corresponding hydroperoxy derivatives. Human macrophages …