The availability of disease modifying therapies for spinal muscular atrophy (SMA) has
created an urgent need to identify clinically meaningful biomarkers. Biomarkers present a …

Abstract N 6-methyladenosine (m 6 A) is the most prevalent, conserved, and abundant RNA
modification of the mRNAs of most eukaryotes, including mammals. Similar to epigenetic …

Spinal motor neurons (MNs) integrate sensory stimuli and brain commands to generate
movements. In vertebrates, the molecular identities of the cardinal MN types such as those …

MicroRNAs (miRNAs) are pivotal regulators of gene expression and are involved in
biological processes spanning from early developmental stages to the intricate process of …

Characterizing the diverse cell types that make up the nervous system is essential for
understanding how the nervous system is structured and ultimately how it functions. The …

The urgent need for new therapies for some devastating neuromuscular diseases (NMDs),
such as Duchenne muscular dystrophy or amyotrophic lateral sclerosis, has led to an …

Long non-coding RNAs (lncRNAs) have gained increasing attention as they exhibit highly
tissue-and cell-type specific expression patterns. LncRNAs are highly expressed in the …

Background: Spinal muscular atrophy (SMA) is a neuromuscular disorder characterized by
the degeneration of the second motor neuron. The phenotype ranges from very severe to …

Positive feedback driven by transcriptional regulation has long been considered a key
mechanism underlying cell lineage segregation during embryogenesis. Using the …

While reports on the generational inheritance of a parental response to stress have been
widely reported in animals, the molecular mechanisms behind this phenomenon have only …