Publisher Summary The Drosophila epidermal growth factor (EGF) receptor (DER/EGFR) is
a single member of the EGFR/ErbB family in the fly genome. The signal peptide and extreme …

The orthogonal axes of Drosophila are established during oogenesis through a hierarchical
series of symmetry-breaking steps, most of which can be traced back to asymmetries …

Sprouty was originally identified as an inhibitor of Drosophila FGF receptor signaling during
tracheal development. By following the capacity of ectopic Sprouty to abolish the pattern of …

Background: The cytoskeleton and associated motors play an important role in the
establishment of intracellular polarity. Microtubule-based transport is required in many cell …

Drosophila has three membrane‐tethered epidermal growth factor (EGF)‐like proteins:
Spitz, Gurken and Keren. Spitz and Gurken have been genetically confirmed to activate the …

Morphogenesis of the respiratory appendages on eggshells of Drosophila species provides
a powerful experimental system for studying how cell sheets give rise to complex three …

Male and female schistosomes are permanently paired while they live in the bloodstream of
their vertebrate hosts. Female schistosomes produce eggs only when they are in intimate …

Recent work on Drosophila oogenesis has begun to reveal how the first asymmetries in
development arise and how these relate to the later events that localise the positional cues …

Early Drosophila development requires two receptor tyrosine kinase (RTK) pathways: the
Torso and the Epidermal growth factor receptor (EGFR) pathways, which regulate terminal …

We describe a mechanism for context-dependent cell signaling mediated by autocrine loops
with positive feedback. We demonstrate that the composition of the extracellular medium can …