[HTML][HTML] Optimal oxygen use in neonatal advanced cardiopulmonary resuscitation—a literature review

D Sankaran, M Rawat, S Lakshminrusimha - Pediatric Medicine, 2023 - pm.amegroups.org
Methods: This narrative review is based on recent and historic English literature in PubMed
and Google scholar over the past 35 years (January 1, 1985–May 1, 2021). Key Content and …

Physiology of neonatal resuscitation: Giant strides with small breaths

D Sankaran, S Lakshminrusimha, OD Saugstad - Seminars in Perinatology, 2022 - Elsevier
The transition of a fetus to a newborn involves a sequence of well-orchestrated physiological
events. Most neonates go through this transition without assistance but 5–10% may require …

[HTML][HTML] Early Hyperoxemia and 2-year Outcomes in Infants with Hypoxic-ischemic Encephalopathy: A Secondary Analysis of the Infant Cooling Evaluation Trial

S Badurdeen, JLY Cheong, S Donath, H Graham… - The Journal of …, 2024 - Elsevier
Objective To determine the causal relationship between exposure to early hyperoxemia and
death or major disability in infants with hypoxic-ischemic encephalopathy (HIE). Study …

Femoral Occlusion during Neonatal Cardiopulmonary Resuscitation Improves Outcomes in an Ovine Model of Perinatal Cardiac Arrest

M Rawat, S Mani, SF Gugino, C Koenigsknecht… - Children, 2023 - mdpi.com
Background: The goal of chest compressions during neonatal resuscitation is to increase
cerebral and coronary blood flow leading to the return of spontaneous circulation (ROSC) …

Randomized Trial of Oxygen Saturation Targets during and after Resuscitation and Reversal of Ductal Flow in an Ovine Model of Meconium Aspiration and Pulmonary …

AL Lesneski, P Vali, ME Hardie, S Lakshminrusimha… - Children, 2021 - mdpi.com
Neonatal resuscitation (NRP) guidelines suggest targeting 85–95% preductal SpO2 by 10
min after birth. Optimal oxygen saturation (SpO2) targets during resuscitation and in the post …

Randomized Trial of 21% versus 100% Oxygen during Chest Compressions Followed by Gradual versus Abrupt Oxygen Titration after Return of Spontaneous …

D Sankaran, EM Giusto, AL Lesneski, ME Hardie… - Children, 2023 - mdpi.com
The combination of perinatal acidemia with postnatal hyperoxia is associated with a higher
incidence of hypoxic-ischemic encephalopathy (HIE) in newborn infants. In neonatal cardiac …

Rapid oxygen titration following cardiopulmonary resuscitation mitigates cerebral overperfusion and striatal mitochondrial dysfunction in asphyxiated newborn lambs

S Badurdeen, R Galinsky, C Roberts, KJ Crossley… - bioRxiv, 2024 - biorxiv.org
Asphyxiated neonates must have oxygenation rapidly restored to limit ongoing hypoxic-
ischemic injury. However, the effects of transient hyperoxia after return of spontaneous …

Neonatal chest compressions: time to act

OD Saugstad - Pediatric Research, 2021 - nature.com
In 1992, American Heart Association (AHA) published new guidelines for newborn
resuscitation and underlined that early administration of 100% oxygen is important:“If …