As people age they become increasingly susceptible to chronic and extremely debilitating
brain diseases. The precise cause of the neuronal degeneration underlying these disorders …

The pathogenesis and etiology of diabetes mellitus (DM) and Alzheimer's disease (AD)
share many common cellular and molecular themes. Recently, a growing body of research …

Numerous studies suggest energy failure and accumulative intracellular waste play a causal
role in the pathogenesis of several neurodegenerative disorders and Alzheimer's disease …

Insulin, a well-known hormone, has been implicated as a regulator of blood glucose levels
for almost a century now. Over the past few decades, the non-glycemic actions of insulin ie …

Alzheimer's Disease (AD) is a devastating neurodegenerative disorder without a cure. Here
we show that mitochondrial respiratory chain complex I is an important small molecule …

Alzheimer's disease is a multifactorial neurodegenerative disease characterized by
progressive cognitive dysfunction. It is the most common form of dementia. The pathologic …

Despite recent FDA approval of anti-amyloid antibodies for Alzheimer's Disease, strategies
that target early molecular mechanisms and could delay or change the disease trajectory …

The cell cycle and its regulators are validated targets for cancer drugs. Reagents that target
cells in a specific cell cycle phase (eg, antimitotics or DNA synthesis inhibitors/replication …

Alzheimer's disease (AD) is a progressive and unremitting neurodegenerative disorder
characterized by memory loss and cognitive impairment. It affects the quality of life of victims …

Background: Emerging evidence supports the hypothesis that metabolism dysfunction is
involved in pathogenesis of Alzheimer's disease (AD). One aspect of metabolic dysfunction …