Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually with over 500,000 deaths. Among the NTDs, some of the …

Parasitic trypanosomatids cause important diseases. Dissecting the biochemistry of these
organisms offers a means of discovering targets against which inhibitors may be designed …

Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite,
Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global …

Background Miltefosine (MIL) is an oral antileishmanial drug used for treatment of visceral
leishmaniasis (VL) in the Indian subcontinent. Recent reports indicate a significant decline in …

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen
independent lines of Leishmania mexicana and one L. infantum line were selected for …

Mammalian target of rapamycin (m TOR) is a central regulator of growth and immunity of
host cells. It's involvement in cancer and tuberculosis is well documented but least explored …

During evolution, both human and plant pathogens have evolved to utilize a diverse range
of carbon sources. N-acetylglucosamine (GlcNAc), an amino sugar, is one of the major …

Highlights•Visceral leishmaniasis is a complicated infectious disease.•Emerging resistance
is one of the main complications in treatment visceral leishmaniasis.•A comprehensive …

Leishmaniasis, a neglected tropical disease, still remains a global concern for the
healthcare sector. The primary causative agents of the disease comprise diverse …

Leishmania donovani is the causative organism of the neglected human disease known as
visceral leishmaniasis which is often fatal, if left untreated. The cysteine biosynthesis …