Emerging fungal infections: new patients, new patterns, and new pathogens

DZP Friedman, IS Schwartz - Journal of Fungi, 2019 - mdpi.com
The landscape of clinical mycology is constantly changing. New therapies for malignant and
autoimmune diseases have led to new risk factors for unusual mycoses. Invasive …

Azole Resistance in Aspergillus fumigatus: A Consequence of Antifungal Use in Agriculture?

S Berger, Y El Chazli, AF Babu, AT Coste - Frontiers in microbiology, 2017 - frontiersin.org
Agricultural industry uses pesticides to optimize food production for the growing human
population. A major issue for crops is fungal phytopathogens, which are treated mainly with …

Trends in agricultural triazole fungicide use in the United States, 1992–2016 and possible implications for antifungal-resistant fungi in human disease

M Toda, KD Beer, KM Kuivila, TM Chiller… - Environmental health …, 2021 - ehp.niehs.nih.gov
Background: The fungus Aspergillus fumigatus (A. fumigatus) is the leading cause of
invasive mold infections, which cause severe disease and death in immunocompromised …

Epidemiological and Genomic Landscape of Azole Resistance Mechanisms in Aspergillus Fungi

D Hagiwara, A Watanabe, K Kamei… - Frontiers in …, 2016 - frontiersin.org
Invasive aspergillosis is a life-threatening mycosis caused by the pathogenic fungus
Aspergillus. The predominant causal species is Aspergillus fumigatus, and azole drugs are …

The Aspergillus fumigatus cell wall integrity signaling pathway: drug target, compensatory pathways, and virulence

V Valiante, J Macheleidt, M Föge… - Frontiers in …, 2015 - frontiersin.org
Aspergillus fumigatus is the most important airborne fungal pathogen, causing severe
infections with invasive growth in immunocompromised patients. The fungal cell wall (CW) …

Diagnosis and treatment of pulmonary aspergillosis syndromes

KC Patterson, ME Strek - Chest, 2014 - Elsevier
Both inherited and acquired immunodeficiency and chronic pulmonary disease predispose
to the development of a variety of pulmonary syndromes in response to Aspergillus, a fungus …

Genesis of azole antifungal resistance from agriculture to clinical settings

MM Azevedo, I Faria-Ramos, LC Cruz… - Journal of agricultural …, 2015 - ACS Publications
Azole fungal resistance is becoming a major public health problem in medicine in recent
years. However, it was known in agriculture since several decades; the extensive use of …

A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B …

D Hagiwara, D Miura, K Shimizu, S Paul, A Ohba… - PLoS …, 2017 - journals.plos.org
Successful treatment of aspergillosis caused by Aspergillus fumigatus is threatened by an
increasing incidence of drug resistance. This situation is further complicated by the finding …

Multidrug resistance in fungi: regulation of transporter-encoding gene expression

S Paul, WS Moye-Rowley - Frontiers in physiology, 2014 - frontiersin.org
A critical risk to the continued success of antifungal chemotherapy is the acquisition of
resistance; a risk exacerbated by the few classes of effective antifungal drugs. Predictably …

Fungicides induced triazole-resistance in Aspergillus fumigatus associated with mutations of TR46/Y121F/T289A and its appearance in agricultural fields

J Ren, X Jin, Q Zhang, Y Zheng, D Lin, Y Yu - Journal of hazardous …, 2017 - Elsevier
Azole resistance in Aspergillus fumigatus is a growing public health problem. The sources of
this resistance have been gained much attention. The present study was conducted to …