Recent calorimetric studies of interactions between small molecules and biomolecular
targets have generated renewed interest in the phenomenon of entropy-enthalpy …

Isothermal titration calorimetry experiments can provide significantly more detailed
information about molecular interactions when combined in global analysis. For example …

Isothermal titration calorimetry (ITC) is a powerful classical method that enables researchers
in many fields to study the thermodynamics of molecular interactions. Primary ITC data …

Isothermal titration calorimetry (ITC) is a powerful and widely used method to measure the
energetics of macromolecular interactions by recording a thermogram of differential heating …

The purpose of this review is to demonstrate the critical importance of understanding protein–
excipient interactions as a key step in the rational design of formulations to stabilize and …

Motivation Computational approaches for identifying the protein–ligand binding affinity can
greatly facilitate drug discovery and development. At present, many deep learning-based …

Small-molecule drug discovery involves the optimization of various physicochemical
properties of a ligand, particularly its binding affinity for its target receptor (or receptors). In …

The emergence of new pathogens and multidrug resistant bacteria is an important public
health issue that requires the development of novel classes of antibiotics. Antimicrobial …

While injectable hydrogels have several advantages in the context of biomedical use, their
generally weak mechanical properties often limit their applications. Herein, we describe in …

The expansion of manufacturing and commercial agriculture alongside rapid globalization
have resulted in the widespread contamination of freshwater supplies with chemical toxins …