Cation-chloride cotransporters in neuronal development, plasticity and disease
Electrical activity in neurons requires a seamless functional coupling between
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …
Calcium-permeable ion channels in pain signaling
The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
[PDF][PDF] The α2δ-1-NMDA receptor complex is critically involved in neuropathic pain development and gabapentin therapeutic actions
Summary α2δ-1, commonly known as a voltage-activated Ca 2+ channel subunit, is a
binding site of gabapentinoids used to treat neuropathic pain and epilepsy. However, it is …
binding site of gabapentinoids used to treat neuropathic pain and epilepsy. However, it is …
Emergence of consciousness from anesthesia through ubiquitin degradation of KCC2 in the ventral posteromedial nucleus of the thalamus
JJ Hu, Y Liu, H Yao, B Cao, H Liao, R Yang… - Nature …, 2023 - nature.com
The emergence of consciousness from anesthesia, once assumed to be a passive process,
is now considered as an active and controllable process. In the present study, we show in …
is now considered as an active and controllable process. In the present study, we show in …
[HTML][HTML] The multifaceted roles of KCC2 in cortical development
KCC2, best known as the neuron-specific chloride-extruder that sets the strength and
polarity of GABAergic currents during neuronal maturation, is a multifunctional molecule that …
polarity of GABAergic currents during neuronal maturation, is a multifunctional molecule that …
[HTML][HTML] GABA actions and ionic plasticity in epilepsy
K Kaila, E Ruusuvuori, P Seja, J Voipio… - Current opinion in …, 2014 - Elsevier
Highlights•Ionic plasticity of GABA signaling relies on short-term and long term changes in E
GABA.•Cl− transport and carboanhydrases play a key role in ionic plasticity and …
GABA.•Cl− transport and carboanhydrases play a key role in ionic plasticity and …
[HTML][HTML] Central nervous system targets: inhibitory interneurons in the spinal cord
Pain is a percept of critical importance to our daily survival. In most cases, it serves both an
adaptive function by helping us respond appropriately in a potentially hostile environment …
adaptive function by helping us respond appropriately in a potentially hostile environment …
[HTML][HTML] Chloride transporters and GABA polarity in developmental, neurological and psychiatric conditions
JT Schulte, CJ Wierenga, H Bruining - Neuroscience & Biobehavioral …, 2018 - Elsevier
Neuronal chloride regulation is a determinant factor for the dynamic tuning of GABAergic
inhibition during and beyond brain development. This regulation is mainly dependent on the …
inhibition during and beyond brain development. This regulation is mainly dependent on the …
Modulation of neuronal activity by phosphorylation of the K–Cl cotransporter KCC2
KT Kahle, TZ Deeb, M Puskarjov, L Silayeva… - Trends in …, 2013 - cell.com
The K–Cl cotransporter KCC2 establishes the low intraneuronal Cl–levels required for the
hyperpolarizing inhibitory postsynaptic potentials mediated by ionotropic γ-aminobutyric …
hyperpolarizing inhibitory postsynaptic potentials mediated by ionotropic γ-aminobutyric …
Epigenetic mechanisms of neural plasticity in chronic neuropathic pain
Neuropathic pain is a challenging clinical problem and remains difficult to treat. Altered gene
expression in peripheral sensory nerves and neurons due to nerve injury is well …
expression in peripheral sensory nerves and neurons due to nerve injury is well …