[HTML][HTML] The unique properties of IgG4 and its roles in health and disease
T Rispens, MG Huijbers - Nature Reviews Immunology, 2023 - nature.com
IgG4 is the least abundant subclass of IgG in human serum and has unique functional
features. IgG4 is largely unable to activate antibody-dependent immune effector responses …
features. IgG4 is largely unable to activate antibody-dependent immune effector responses …
[HTML][HTML] IgG subclasses and allotypes: from structure to effector functions
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human
serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ …
serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ …
IgG4 production is confined to human IL-10–producing regulatory B cells that suppress antigen-specific immune responses
BACKGROUND: IL-10–producing regulatory B cells suppress immune responses, and lack
of these cells leads to exacerbated symptoms in mouse models of chronic inflammation …
of these cells leads to exacerbated symptoms in mouse models of chronic inflammation …
Helminth infections and host immune regulation
HJ McSorley, RM Maizels - Clinical microbiology reviews, 2012 - Am Soc Microbiol
Helminth parasites infect almost one-third of the world's population, primarily in tropical
regions. However, regions where helminth parasites are endemic record much lower …
regions. However, regions where helminth parasites are endemic record much lower …
Allergic rhinitis and its impact on asthma (ARIA) 2008
Allergic rhinitis is a symptomatic disorder of the nose induced after allergen exposure by an
immunoglobulin E (IgE)-mediated inflammation of the membranes lining the nose (1). It was …
immunoglobulin E (IgE)-mediated inflammation of the membranes lining the nose (1). It was …
Helminth parasites–masters of regulation
RM Maizels, A Balic, N Gomez‐Escobar… - Immunological …, 2004 - Wiley Online Library
Immune regulation by parasites is a global concept that includes suppression, diversion,
and conversion of the host immune response to the benefit of the pathogen. While many …
and conversion of the host immune response to the benefit of the pathogen. While many …
IgG4 breaking the rules
RC Aalberse, J Schuurman - Immunology, 2002 - Wiley Online Library
Summary Immunoglobulin G4 (IgG4) antibodies have been known for some time to be
functionally monovalent. Recently, the structural basis for this monovalency has been …
functionally monovalent. Recently, the structural basis for this monovalency has been …
Immunological modulation and evasion by helminth parasites in human populations
Helminth parasites are highly prevalent in human communities in developing countries. In
an endemic area an infected individual may harbour parasitic worms for most of his or her …
an endemic area an infected individual may harbour parasitic worms for most of his or her …
[HTML][HTML] Parasitic helminth infections and the control of human allergic and autoimmune disorders
RM Maizels - Clinical Microbiology and Infection, 2016 - Elsevier
The profile of global health today presents a striking reciprocal distribution between parasitic
diseases in many of the world's lower-income countries, and ever-increasing levels of …
diseases in many of the world's lower-income countries, and ever-increasing levels of …
[HTML][HTML] On the role of IgG4 in inflammatory conditions: lessons for IgG4-related disease
DC Trampert, LM Hubers, SFJ van de Graaf… - … et Biophysica Acta (BBA …, 2018 - Elsevier
The pathophysiology of immunoglobulin G4-related disease (IgG4-RD) and its most
common manifestations, IgG4-associated (sclerosing) cholangitis and autoimmune …
common manifestations, IgG4-associated (sclerosing) cholangitis and autoimmune …