Nm23/NDP kinases A and B encoded by the Nme1/Nme2 genes are multifunctional
enzymes responsible for the majority of NDP kinase activity in mammals. This review …

Substantial effort has been directed at elucidating the functions of the products of the Nm23
tumor metastasis suppressor genes over the past two decades, with the ultimate goal of …

Occult metastases are a major cause of cancer mortality, even among patients undergoing
curative resection. Therefore, practical strategies to target the growth and persistence of …

Mesenchymal stem cells (MSCs) can differentiate into different types of cells and thus have
tremendous potential for cell therapy and tissue engineering. 5-Azacytidine (5-aza), a DNA …

Transient accumulation of extracellular ATP reflects both release of ATP from intracellular
stores and altered rates of ATP metabolism by ecto‐enzymes. Ecto‐nucleoside triphosphate …

The ubiquitously expressed nucleoside diphosphate kinases (Nm23/NDPK/Awd) are a large
family of multifunctional enzymes implicated in nucleic acid metabolism and in normal and …

An elevated serum level of NM23‐H1 protein is found in acute myelogenous leukemia
(AML), and predicts a poor treatment outcome in AML patients. To investigate the potential …

Nm23-H1 plays complex roles in the development of diverse cancers including breast
carcinoma, high-grade lymphomas, and acute myeloid leukemia (AML). In the case of AML …

Nm23-H1 encodes nucleoside diphosphate kinase A (NDPK-A) and is known to have a
metastasis suppressive activity in many tumor cells. However, it has many other functions as …

AIMS: Nm23-H1 is a suppressor of metastasis that has been implicated in the regulation of
proliferation and differentiation of hematopoietic cells, although specific mechanisms for …