Shadow enhancers are seemingly redundant transcriptional cis-regulatory elements that
regulate the same gene and drive overlapping expression patterns. Recent studies have …

Following fertilization, the two specified gametes must unite to create an entirely new
organism. The genome is initially transcriptionally quiescent, allowing the zygote to be …

The prevailing view of metazoan gene regulation is that individual genes are independently
regulated by their own dedicated sets of transcriptional enhancers. Past studies have …

The reduction of dinitrogen to ammonia by nitrogenase reflects a complex choreography
involving two component proteins, MgATP and reductant. At center stage of this process …

A long-standing question in gene regulation is how remote enhancers communicate with
their target promoters, and specifically how chromatin topology dynamically relates to gene …

Transcription is episodic, consisting of a series of discontinuous bursts. Using live-imaging
methods and quantitative analysis, we examine transcriptional bursting in living Drosophila …

The Drosophila blastoderm and the vertebrate neural tube are archetypal examples of
morphogen-patterned tissues that create precise spatial patterns of different cell types. In …

The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved
cytokines whose signalling modulates cell fate decision-making across varying cellular …

Comparative genome analyses reveal that organismal complexity scales not with gene
number but with gene regulation. Recent efforts indicate that the human genome likely …

The prevailing view of metazoan gene regulation is that transcription is facilitated through
the formation of static activator complexes at distal regulatory regions. Here, we employed …