Mitochondrial dysfunction has been associated with neurodegeneration in Parkinson's
disease (PD) for over 30 years. Despite this, the role of mitochondrial dysfunction as an …

The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

The amyloid aggregation of α-synuclein (α S), related to Parkinson's disease, can be
catalyzed by lipid membranes. Despite the importance of lipid surfaces, the 3D-structure and …

Accumulation of the neuronal presynaptic protein alpha-synuclein within proteinaceous
inclusions represents the key histophathological hallmark of a spectrum of …

Mitochondria, with their intricate networks of functions and information processing, are
pivotal in both health regulation and disease progression. Particularly, mitochondrial …

Alpha-Synuclein (αSyn) is a protein whose function is still debated, as well as its role in
modulation of mitochondrial function in both physiological and pathological conditions …

An intrinsically disordered neuronal protein α-synuclein (αSyn) is known to cause
mitochondrial dysfunction, contributing to loss of dopaminergic neurons in Parkinson's …

Voltage-dependent anion channel (VDAC) is the most ubiquitous channel at the
mitochondrial outer membrane, and is believed to be the pathway for calcium entering or …

Voltage-dependent anion channel (VDAC) is the major pathway for the transport of ions and
metabolites across the mitochondrial outer membrane. Among the three known mammalian …

Mitochondria are essential for neuronal survival and mitochondrial dysfunction is a hallmark
of neurodegeneration. The loss in mitochondrial energy production, oxidative stress, and …