The organization, regulation and dynamical responses of biological systems are in many
cases too complex to allow intuitive predictions and require the support of mathematical …

Biochemical systems theory (BST) is the foundation for a set of analytical andmodeling tools
that facilitate the analysis of dynamic biological systems. This paper depicts major …

A true understanding of genetic and metabolic function and design is facilitated by
mathematical and computational methods for analyzing biochemical systems. This hands-on …

This text emphasises the importance of staying informed about Saccharomyces cerevisiae
as it provides the intellectual basis for much of the molecular and cellular biology of …

Mathematical modeling is one of the key methodologies of metabolic engineering. Based on
a given metabolic model different computational tools for the simulation, data evaluation …

Biochemical systems are among of the oldest application areas of mathematical modeling.
Spanning a time period of over one hundred years, the repertoire of options for structuring a …

Motivation: Modern methods of genomics have produced an unprecedented amount of raw
data. The interpretation and explanation of these data constitute a major, well-recognized …

Experimental and clinical data on purine metabolism are collated and analyzed with three
mathematical models. The first model is the result of an attempt to construct a traditional …

Background The problem of estimating the parameters of dynamic models of complex
biological systems from time series data is becoming increasingly important. Methods and …

Mathematical tools that involve the determination of systemic responses to small changes in
metabolites or enzymes have demonstrated their utility for analyzing metabolic pathways …