Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …

This article reviews recent developments in the application of cell-free DNA-based liquid
biopsies to neurological diseases. Over the past few decades, an explosion of interest in the …

BACKGROUND. Accurate detection of graft-versus-host disease (GVHD) is a major
challenge in the management of patients undergoing hematopoietic stem cell …

Blood cell counts often fail to report on immune processes occurring in remote tissues. Here,
we use immune cell type-specific methylation patterns in circulating cell-free DNA (cfDNA) …

The pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to
the islet β cell. Impairments in propeptide processing and secretory function, along with the …

Circulating cell-free DNA (cfDNA) fragments are a biological analyte with extensive utility in
diagnostic medicine. Understanding the source of cfDNA and mechanisms of release is …

Cancer inflicts damage to surrounding normal tissues, which can culminate in fatal organ
failure. Here, we demonstrate that cell death in organs affected by cancer can be detected …

The risk of early recurrent events after stroke remains high despite currently established
secondary prevention strategies. Risk is particularly high in patients with atherosclerosis …

Type 1 diabetes is characterised by autoimmune-mediated destruction of pancreatic β-cell
mass. With the advent of insulin therapy a century ago, type 1 diabetes changed from a …

Pancreatic beta cells play a central role in regulating glucose homeostasis by secreting the
hormone insulin. Failure of beta cells due to reduced function and mass and the resulting …