The somatosensory system decodes a wide range of tactile stimuli and thus endows us with
a remarkable capacity for object recognition, texture discrimination, sensory-motor feedback …

Neurons in the spinal dorsal horn process sensory information, which is then transmitted to
several brain regions, including those responsible for pain perception. The dorsal horn …

Pain thresholds are, in part, set as a function of emotional and internal states by descending
modulation of nociceptive transmission in the spinal cord. Neurons of the rostral …

The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different
CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy …

Human genetic studies show that the voltage gated sodium channel 1.7 (Nav1. 7) is a key
molecular determinant of pain sensation. However, defining the Nav1. 7 contribution to …

Spinal cord sensory synapses are glutamatergic, but previous studies have found a great
diversity in synaptic vesicle structure and have suggested additional neurotransmitters. The …

CCL2 chemokine and its receptor CCR2 may contribute to neuropathic pain development.
We tested the hypothesis that injury to peripheral nerves triggers CCL2 release from …

2.1. 2.1. Light microscopy 2.1. 2.2. Electron microscopy 2.1. 3. Acetylcholine 2.1. 3.1. Light
microscopy 2.1. 3.2. Electron microscopy 2.1. 4. Coexistence of GABA, giycine and …

Maladaptive plasticity within the dorsal horn (DH) of the spinal cord is a key substrate for
development of neuropathic pain following peripheral nerve injury. Advances in genetic …

Antibodies with two distinet binding specificities have great potential for a wide range of
clinical applications as targeting agents for in vitro and in vivo immunodiagnosis and …