[HTML][HTML] Selected approaches to disrupting protein–protein interactions within the MAPK/RAS pathway
SJ Harwood, CR Smith, JD Lawson… - International Journal of …, 2023 - mdpi.com
Within the MAPK/RAS pathway, there exists a plethora of protein–protein interactions (PPIs).
For many years, scientists have focused efforts on drugging KRAS and its effectors in hopes …
For many years, scientists have focused efforts on drugging KRAS and its effectors in hopes …
An Improved PDE6D Inhibitor Combines with Sildenafil To Inhibit KRAS Mutant Cancer Cell Growth
P Kaya, E Schaffner-Reckinger… - Journal of Medicinal …, 2024 - ACS Publications
The trafficking chaperone PDE6D (or PDEδ) was proposed as a surrogate target for K-Ras,
leading to the development of a series of inhibitors that block its prenyl binding pocket …
leading to the development of a series of inhibitors that block its prenyl binding pocket …
An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
P Kaya, E Schaffner-Reckinger, GB Manoharan… - bioRxiv, 2023 - biorxiv.org
The trafficking chaperone PDE6D (or PDEδ) was proposed as a surrogate target for K-Ras,
leading to the development of a series of inhibitors that block its prenyl-binding pocket …
leading to the development of a series of inhibitors that block its prenyl-binding pocket …
[PDF][PDF] Identification of a novel glycolysis-related prognostic signature for predicting prognosis and tumor microenvironment of lung adenocarcinoma
B Dong, X Zhu, K Li, M Chen - 2022 - scholar.archive.org
Background: Glycolysis affects tumor growth, invasion, treatment resistance, and the tumor
microenvironment. In this study, we aimed to construct a glycolysis-related prognostic …
microenvironment. In this study, we aimed to construct a glycolysis-related prognostic …