According to the 'hygiene hypothesis', the decreasing incidence of infections in western
countries and more recently in developing countries is at the origin of the increasing …

Although genetic susceptibility explains the clustering of multiple sclerosis (MS) cases within
families and the sharp decline in risk with increasing genetic distance, it cannot fully explain …

The purpose of studying the epidemiology of multiple sclerosis (MS) is twofold. First, it is
important to understand clearly the natural history of the illness in order to assist patients in …

Background Multiple sclerosis (MS) appears to develop in genetically susceptible
individuals as a result of environmental exposures. Epstein-Barr virus (EBV) infection is an …

Studies in Canada have provided strong evidence that environmental factors act at a
population level to influence the unusual geographical distribution of multiple sclerosis (MS) …

Objective To characterize the association between infectious mononucleosis (IM), a frequent
clinical manifestation of primary Epstein–Barr virus infection after childhood, and the risk for …

ContextInfection with Epstein-Barr virus (EBV) has been associated with an increased risk of
multiple sclerosis (MS), but the temporal relationship remains unclear. ObjectiveTo …

This second edition of Epidemiologic Methods offers a rigorous introduction to the concepts
and tools of epidemiologic research. Aimed chiefly at future epidemiologists, the book offers …

Multiple sclerosis (MS) is a common, complex neurological disease. Epidemiological data
implicate both genetic and environmental factors in the etiology of MS, with various factors …

Background The full spectrum of clinical manifestations and outcome, and the potential
importance of regional or demographic features or viral triggers in paediatric multiple …