International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …
therapeutics and various drugs in development. Their diversity of structure and function …
5-HT1, 5-HT2, 5-HT3 and 5-HT7 receptors and their role in the modulation of pain response in the central nervous system
JL Cortes-Altamirano… - Current …, 2018 - ingentaconnect.com
Background: The aim of this review was to identify the mechanisms by which serotonin
receptors involved at the central level are able to modulate the nociceptive response. Pain is …
receptors involved at the central level are able to modulate the nociceptive response. Pain is …
Role of 5-HT receptors in neuropathic pain: potential therapeutic implications
QQ Liu, XX Yao, SH Gao, R Li, BJ Li, W Yang… - Pharmacological …, 2020 - Elsevier
HT plays a crucial role in the progress and adjustment of pain both centrally and
peripherally. The therapeutic action of the 5-HT receptorsagonist and antagonist in …
peripherally. The therapeutic action of the 5-HT receptorsagonist and antagonist in …
Multiple roles of serotonin in pain control mechanisms—implications of 5-HT7 and other 5-HT receptor types
F Viguier, B Michot, M Hamon, S Bourgoin - European journal of …, 2013 - Elsevier
Abstract Among monoamine neurotransmitters, serotonin (5-HT) is known to play complex
modulatory roles in pain signaling mechanisms since the first reports, about forty years ago …
modulatory roles in pain signaling mechanisms since the first reports, about forty years ago …
A systematic review on descending serotonergic projections and modulation of spinal nociception in chronic neuropathic pain and after spinal cord stimulation
L Heijmans, MR Mons, EA Joosten - Molecular pain, 2021 - journals.sagepub.com
Chronic neuropathic pain is a debilitating ordeal for patients worldwide and
pharmacological treatment efficacy is still limited. As many pharmacological interventions for …
pharmacological treatment efficacy is still limited. As many pharmacological interventions for …
The role of descending pain modulation in chronic primary pain: potential application of drugs targeting serotonergic system
ZY Tao, PX Wang, SQ Wei, RJ Traub, JF Li… - Neural …, 2019 - Wiley Online Library
Chronic primary pain (CPP) is a group of diseases with long‐term pain and functional
disorders but without structural or specific tissue pathologies. CPP is becoming a serious …
disorders but without structural or specific tissue pathologies. CPP is becoming a serious …
[HTML][HTML] Monoamines as drug targets in chronic pain: focusing on neuropathic pain
Monoamines are involved in regulating the endogenous pain system and indeed, peripheral
and central monoaminergic dysfunction has been demonstrated in certain types of pain …
and central monoaminergic dysfunction has been demonstrated in certain types of pain …
[HTML][HTML] Role of descending serotonergic fibers in the development of pathophysiology after spinal cord injury (SCI): Contribution to chronic pain, spasticity, and …
GNK Fauss, KE Hudson, JW Grau - Biology, 2022 - mdpi.com
Simple Summary Fiber pathways that descend from the brain to the spinal cord drive motor
behavior and modulate incoming sensory signals and the capacity to change (plasticity). A …
behavior and modulate incoming sensory signals and the capacity to change (plasticity). A …
Serotonergic modulation of nociceptive circuits in spinal cord dorsal horn
R Bardoni - Current Neuropharmacology, 2019 - ingentaconnect.com
Background: Despite the extensive number of studies performed in the last 50 years, aimed
at describing the role of serotonin and its receptors in pain modulation at the spinal cord …
at describing the role of serotonin and its receptors in pain modulation at the spinal cord …
Anti-inflammatory and antinociceptive activities of Croton urucurana Baillon bark
KW Cordeiro, JL Felipe, KF Malange… - Journal of …, 2016 - Elsevier
Abstract Ethnopharmacological relevance Croton urucurana (Euphorbiaceae) is popularly
used in Brazil to treat inflammatory processes, pain, and gastric ulcers. Aim of study To …
used in Brazil to treat inflammatory processes, pain, and gastric ulcers. Aim of study To …