A review of brain imaging biomarker genomics in Alzheimer's disease: implementation and perspectives

L Li, X Yu, C Sheng, X Jiang, Q Zhang, Y Han… - Translational …, 2022 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disease with phenotypic
changes closely associated with both genetic variants and imaging pathology. Brain …

The effects of environmental factors associated with childhood urbanicity on brain structure and cognition

X Zhang, H Yan, H Yu, Y Zhang, HY Tan, D Zhang… - BMC psychiatry, 2023 - Springer
Urbanization is a trend lasting for more than one century worldwide. Four hundred ninety
male and female adult Chinese Han participants with different urban and rural childhoods …

Genome-wide association study of quantitative biomarkers identifies a novel locus for Alzheimer's disease at 12p12. 1

B Lee, X Yao, L Shen… - BMC genomics, 2022 - Springer
Background Genetic study of quantitative biomarkers in Alzheimer's Disease (AD) is a
promising method to identify novel genetic factors and relevant endophenotypes, which …

Hippocampal Subregion and Gene Detection in Alzheimer's Disease Based on Genetic Clustering Random Forest

J Li, W Liu, L Cao, H Luo, S Xu, P Bao, X Meng… - Genes, 2021 - mdpi.com
The distinguishable subregions that compose the hippocampus are differently involved in
functions associated with Alzheimer's disease (AD). Thus, the identification of hippocampal …

Morphometry of medial temporal lobe subregions using high‐resolution T2‐weighted MRI in ADNI3: Why, how, and what's next?

PA Yushkevich, R Ittyerah, Y Li… - Alzheimer's & …, 2024 - Wiley Online Library
This paper for the 20th anniversary of the Alzheimer's Disease Neuroimaging Initiative
(ADNI) provides an overview of magnetic resonance imaging (MRI) of medial temporal lobe …

Integration of tissue-specific multi-omics data implicates brain targets for complex neuropsychiatric traits

S Cong, Z Sang, L Cao, J Yuan, Y Li, H Liang, X Yao - medRxiv, 2023 - medrxiv.org
Genome-wide association studies (GWAS) have uncovered genetic variants susceptible to
brain disorders. However, due to the complex pathogenesis of these diseases and …

Genetic Influence Underlying Brain Connectivity Phenotype: A Study on Two Age-Specific Cohorts

S Cong, X Yao, L Xie, J Yan, L Shen… - Frontiers in …, 2022 - frontiersin.org
Background: Human brain structural connectivity is an important imaging quantitative trait for
brain development and aging. Mapping the network connectivity to the phenotypic variation …