The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …

Cardiac diseases are the leading causes of death, with a growing number of cases
worldwide, posing a challenge for both healthcare and research. Therefore, the most …

The regulation of intracellular calcium (Ca2+) homeostasis is fundamental to maintain
normal functions in many cell types. The ryanodine receptor (RyR), the largest intracellular …

In situations of stress the heart beats faster and stronger. According to Marks and
colleagues, this response is, to a large extent, the consequence of facilitated Ca2+ release …

The 12-kDa FK506-binding proteins (FKBP12 and FKBP12. 6) are regulatory subunits of
ryanodine receptor (RyR) Ca 2+ release channels. To investigate the structural basis of …

ABSTRACT Ryanodine receptor (RyR) Ca2+ channels are central to striated muscle
function and influence signalling in neurons and other cell types. Beneficially low RyR …

Mutations in RyR2 are causative of an inherited disorder which often results in sudden
cardiac death. Dysfunctional channel behaviour has been the subject of many investigations …

Aims The cardiac ryanodine receptor (RyR2), which mediates intracellular Ca2+ release to
trigger cardiomyocyte contraction, participates in development of acquired and inherited …

Oligomerization of all three mammalian ryanodine receptor isoforms, a structural
requirement for normal intracellular Ca2+ release channel function, is displayed by the …

The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …