Plant Derived Bioactive Compounds, Their Anti-Cancer Effects and In Silico Approaches as an Alternative Target Treatment Strategy for Breast Cancer: An Updated …

V Shrihastini, P Muthuramalingam, S Adarshan… - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer is one of the leading causes of death among women
worldwide. Breast cancer may be provoked due to several physical, chemical and …

The microenvironment of brain metastases from solid tumors

ES Srinivasan, K Deshpande, J Neman… - Neuro-oncology …, 2021 - academic.oup.com
Brain metastasis (BrM) is an area of unmet medical need that poses unique therapeutic
challenges and heralds a dismal prognosis. The intracranial tumor microenvironment (TME) …

Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis

F Qu, SC Brough, W Michno, CJ Madubata… - Nature Cell …, 2023 - nature.com
Brain metastases represent an important clinical problem for patients with small-cell lung
cancer (SCLC). However, the mechanisms underlying SCLC growth in the brain remain …

A new time dimension in the fight against metastasis

Z Diamantopoulou, A Gvozdenovic, N Aceto - Trends in Cell Biology, 2023 - cell.com
Despite advances in uncovering vulnerabilities, identifying biomarkers, and developing
more efficient treatments, cancer remains a threat because of its ability to progress while …

Nanointegrative in situ reprogramming of Tumor-intrinsic lipid Droplet Biogenesis for Low-Dose Radiation-activated ferroptosis immunotherapy

Q Zhang, X Wang, Y Zhao, Z Cheng, D Fang, Y Liu… - ACS …, 2023 - ACS Publications
Low-dose radiotherapy (LDR) has shown significant implications for inflaming the
immunosuppressive tumor microenvironment (TME). Surprisingly, we identify that FABP …

Interplay between desmoglein2 and hypoxia controls metastasis in breast cancer

PH Chang, MC Chen, YP Tsai… - Proceedings of the …, 2021 - National Acad Sciences
Metastasis is the major cause of cancer death. An increased level of circulating tumor cells
(CTCs), metastatic cancer cells that have intravasated into the circulatory system, is …

In vitro 3D spheroid model preserves tumor microenvironment of hot and cold breast cancer subtypes

H Dhandapani, A Siddiqui, S Karadkar… - Advanced Healthcare …, 2023 - Wiley Online Library
Dynamic interaction of cancer, immune, and stromal cells with extracellular matrix
components modulates and resists the response of standard care therapies. To mimic this …

Arsenic activated GLUT1-mTORC1/HIF-1α-PKM2 positive feedback networks promote proliferation and migration of bladder epithelial cells

Z Fu, M Deng, Q Zhou, S Li, W Liu, S Cao… - Science of The Total …, 2024 - Elsevier
Arsenic (As) is recognized as a potent environmental contaminant associated with bladder
carcinogenesis. However, its molecular mechanism remains unclear. Metabolic …

A narrative review of circulating tumor cells clusters: a key morphology of cancer cells in circulation promote hematogenous metastasis

Q Chen, J Zou, Y He, Y Pan, G Yang, H Zhao… - Frontiers in …, 2022 - frontiersin.org
Circulating tumor cells (CTCs) that survive in the blood are playing an important role in the
metastasis process of tumor. In addition, they have become a tool for tumor diagnosis …

Small Molecule RNA Degraders

J Bonet‐Aleta, T Maehara, BA Craig… - Angewandte Chemie …, 2024 - Wiley Online Library
RNA is a central molecule in life, involved in a plethora of biological processes and playing
a key role in many diseases. Targeting RNA emerges as a significant endeavor in drug …