Semaphorins and their receptors: from axonal guidance to atherosclerosis

S Hu, L Zhu - Frontiers in physiology, 2018 - frontiersin.org
Semaphorins are a large family of secreted, transmembrane, or GPI-anchored proteins
initially identified as axon guidance cues signaling through their receptors, neuropilins, and …

[HTML][HTML] miR-19a/b and miR-20a promote wound healing by regulating the inflammatory response of keratinocytes

D Li, H Peng, LE Qu, P Sommar, A Wang, T Chu… - Journal of Investigative …, 2021 - Elsevier
Persistent and impaired inflammation impedes tissue healing and is a characteristic of
chronic wounds. A better understanding of the mechanisms controlling wound inflammation …

SEMA7a primes integrin α5β1 engagement instructing fibroblast mechanotransduction, phenotype and transcriptional programming

P Hu, AE Miller, CR Yeh, GC Bingham, M Civelek… - Matrix Biology, 2023 - Elsevier
Integrins are cellular receptors that bind the extracellular matrix (ECM) and facilitate the
transduction of biochemical and biophysical microenvironment cues into cellular responses …

Vascular semaphorin 7A upregulation by disturbed flow promotes atherosclerosis through endothelial β1 integrin

S Hu, Y Liu, T You, J Heath, L Xu, X Zheng… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—Accumulating evidence suggests a role of semaphorins in vascular homeostasis.
Here, we investigate the role of Sema7A (semaphorin 7A) in atherosclerosis and its …

Macphatics and PoEMs in postpartum mammary development and tumor progression

AM Elder, AR Stoller, SA Black, TR Lyons - Journal of mammary gland …, 2020 - Springer
Postpartum mammary gland involution is a mammalian tissue remodeling event that occurs
after pregnancy and lactation to return the gland to the pre-pregnant state. This event is …

Comparison and combination of blood DNA methylation at smoking‐associated genes and at lung cancer‐related genes in prediction of lung cancer mortality

Y Zhang, LP Breitling, Y Balavarca… - … journal of cancer, 2016 - Wiley Online Library
Epigenome‐wide association studies have established methylation patterns related to
smoking, the major risk factor of lung cancer (LC), which are distinct from methylation …

[HTML][HTML] Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis

Q Lu, Z Liu, L Zhao, L Xu, C Liu, L Li, Y Cao, F Li… - Molecular …, 2023 - Elsevier
Objective Obesity and related diseases are becoming a growing risk for public health
around the world due to the westernized lifestyle. Sema7A, an axonal guidance molecule …

Suppression of tumor-derived Semaphorin 7A and genetic ablation of host-derived Semaphorin 7A impairs tumor progression in a murine model of advanced breast …

R Garcia-Areas, S Libreros… - International …, 2017 - spandidos-publications.com
Solid tumors can generate a plethora of neurogenesis-related molecules that enhance their
growth and metastasis. Among them, we have identified axonal guidance molecule …

A Comprehensive Prognostic Analysis of Tumor-Related Blood Group Antigens in Pan-Cancers Suggests That SEMA7A as a Novel Biomarker in Kidney Renal Clear …

Y Wang, C Li, X Qi, Y Yao, L Zhang, G Zhang… - International Journal of …, 2022 - mdpi.com
Blood group antigen is a class of heritable antigenic substances present on the erythrocyte
membrane. However, the role of blood group antigens in cancer prognosis is still largely …

Semaphorin 7a is a biomarker for recurrence in postpartum breast cancer

VF Borges, J Hu, C Young, J Maggard, HJ Parris… - NPJ breast …, 2020 - nature.com
Breast cancer is a global health threat and cases diagnosed in women during the years after
childbirth, or postpartum breast cancers (PPBCs), have high risk for metastasis. In preclinical …