Atherosclerosis (AS) is the major form of cardiovascular disease and the leading cause of
morbidity and mortality in countries around the world. Atherosclerosis combines the …

The nuclear receptors (NRs) belong to a vast family of evolutionary conserved proteins
acting as ligand-activated transcription factors. Functionally, NRs are essential in …

Rationale: Blood flow–induced shear stress controls endothelial cell (EC) physiology during
atherosclerosis via transcriptional mechanisms that are incompletely understood. The …

Diabetes mellitus (DM) is the most important metabolic disease with major threat for public
health and increased risk of premature death. The prevalence of DM steadily rises in …

Malignant or accelerated hypertension is the most severe form of hypertension, defined
clinically by very high blood pressure (diastolic above 130 mm Hg) accompanied by bilateral …

Blood vessels span throughout the body to nourish tissue cells and to provide gateways for
immune surveillance. Endothelial cells that line capillaries have the remarkable capacity to …

Blood flow produces shear stress exerted on the endothelial layer of the vessels. Spatial
characterization of the endothelial proteome is required to uncover the mechanisms of …

In regenerative medicine, autologous peripheral blood derived endothelial colony forming
cells (PB-derived ECFC) represent a promising source of endothelial cells (EC) for pre …

Purpose of review Endothelial dysfunction is intimately related to the development of various
cardiovascular diseases, including hypertension, and is often used as a target for …

Despite the currently available pharmacotherapies, today, thirty percent of worldwide deaths
are due to cardiovascular diseases (CVDs), whose primary cause is atherosclerosis, an …