Targeting the mitochondria in chronic respiratory diseases

DK Chellappan, KR Paudel, NW Tan, KS Cheong… - Mitochondrion, 2022 - Elsevier
Mitochondria are one of the basic essential components for eukaryotic life survival. It is also
the source of respiratory ATP. Recently published studies have demonstrated that …

Nanoformulations-based metronomic chemotherapy: mechanism, challenges, recent advances, and future perspectives

VK Panthi, K Dua, SK Singh, G Gupta, PM Hansbro… - Pharmaceutics, 2023 - mdpi.com
Cancer-related death is a significant health and economic burden worldwide, and some
conventional chemotherapy is associated with limited effectiveness in completely curing …

Anti‐inflammatory and anticancer activities of Naringenin‐loaded liquid crystalline nanoparticles in vitro

R Wadhwa, KR Paudel, LH Chin… - Journal of food …, 2021 - Wiley Online Library
In this study, we had developed Naringenin‐loaded liquid crystalline nanoparticles (LCNs)
and investigated the anti‐inflammatory and anticancer activities of Naringenin‐LCNs against …

Rutin loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro

KR Paudel, R Wadhwa, XN Tew, NJX Lau… - Life sciences, 2021 - Elsevier
Non-small cell lung cancer (NSCLC) is one of the major causes of cancer-related mortality
globally. Despite the availability of therapeutic options, the improvement in patient survival is …

Berberine-loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro

KR Paudel, M Mehta, GHS Yin, LL Yen… - … Science and Pollution …, 2022 - Springer
Non-small cell lung cancer (NSCLC) is reported to have a high incidence rate and is one of
the most prevalent types of cancer contributing towards 85% of all incidences of lung cancer …

Attenuation of cigarette-smoke-induced oxidative stress, senescence, and inflammation by berberine-loaded liquid crystalline nanoparticles: in vitro study in 16HBE …

KR Paudel, N Panth, B Manandhar, SK Singh, G Gupta… - Antioxidants, 2022 - mdpi.com
Cigarette smoke is considered a primary risk factor for chronic obstructive pulmonary
disease. Numerous toxicants present in cigarette smoke are known to induce oxidative …

Agarwood oil nanoemulsion attenuates cigarette smoke-induced inflammation and oxidative stress markers in BCi-NS1. 1 airway epithelial cells

G De Rubis, KR Paudel, B Manandhar, SK Singh… - Nutrients, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory
disease characterized by frequent exacerbations and symptoms such as cough and …

In vitro anti-cancer activity of a polyherbal preparation, VEDICINALS® 9, against A549 human lung adenocarcinoma cells

KR Paudel, R Rajput, G De Rubis, VSRR Allam… - … -Research and Practice, 2023 - Elsevier
Purpose Non-small cell lung cancer (NSCLC) is among the leading causes of morbidity and
mortality worldwide. Despite the availability of several treatment options, the five-year …

Zerumbone-incorporated liquid crystalline nanoparticles inhibit proliferation and migration of non-small-cell lung cancer in vitro

B Manandhar, KR Paudel, DD Clarence… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer is the second most prevalent type of cancer and is responsible for the highest
number of cancer-related deaths worldwide. Non-small-cell lung cancer (NSCLC) makes up …

Characterization, Anti-lung Cancer Activity, and Cytotoxicity of Bio-synthesized Copper Nanoparticles by Thymus fedtschenkoi Leaf Extract

A Dehnoee, R Javad Kalbasi, MM Zangeneh… - Journal of Cluster …, 2024 - Springer
Today propose diverse techniques to remedy cancer and nanotechnology is one of the most
effective cancer treatments. In this study, we detail a simple and environmentally friendly …