[HTML][HTML] Targeting KRAS mutant cancers: from druggable therapy to drug resistance
C Zhu, X Guan, X Zhang, X Luan, Z Song, X Cheng… - Molecular cancer, 2022 - Springer
Abstract Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) is the most frequently
mutated oncogene, occurring in a variety of tumor types. Targeting KRAS mutations with …
mutated oncogene, occurring in a variety of tumor types. Targeting KRAS mutations with …
At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy
N Vasan, LC Cantley - Nature Reviews Clinical Oncology, 2022 - nature.com
Numerous agents targeting various phosphatidylinositol 3-kinase (PI3K) pathway
components, including PI3K, AKT and mTOR, have been tested in oncology clinical trials …
components, including PI3K, AKT and mTOR, have been tested in oncology clinical trials …
Targeting the PI3K/AKT/mTOR signaling pathway in the treatment of human diseases: Current status, trends, and solutions
J Huang, L Chen, J Wu, D Ai, JQ Zhang… - Journal of medicinal …, 2022 - ACS Publications
The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR) pathway is one of the most important intracellular pathways involved in …
rapamycin (mTOR) pathway is one of the most important intracellular pathways involved in …
[HTML][HTML] Immunomodulatory properties of PI3K/AKT/mTOR and MAPK/MEK/ERK inhibition augment response to immune checkpoint blockade in melanoma and triple …
Hyperactivation of PI3K/AKT/mTOR and MAPK/MEK/ERK signaling pathways is commonly
observed in many cancers, including triple-negative breast cancer (TNBC) and melanoma …
observed in many cancers, including triple-negative breast cancer (TNBC) and melanoma …
Design, synthesis, and evaluation of potent, selective, and bioavailable AKT kinase degraders
The serine/threonine kinase AKT functions as a critical node of the phosphatidylinositol 3-
kinase (PI3K)/AKT/mammalian target of rapamycin (m-TOR) signaling pathway. Aberrant …
kinase (PI3K)/AKT/mammalian target of rapamycin (m-TOR) signaling pathway. Aberrant …
Discovery of potent, selective, and in vivo efficacious AKT kinase protein degraders via structure–activity relationship studies
We recently reported a potent, selective, and in vivo efficacious AKT degrader, MS21, which
is a von Hippel–Lindau (VHL)-recruiting proteolysis targeting chimera (PROTAC) based on …
is a von Hippel–Lindau (VHL)-recruiting proteolysis targeting chimera (PROTAC) based on …
[HTML][HTML] Targeting Akt/PKB in pediatric tumors: A review from preclinical to clinical trials
The serine/threonine kinase Akt is a major player in the phosphoinositide 3-kinase
(PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway, and its modulation …
(PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway, and its modulation …
Exploring degradation of mutant and wild-type epidermal growth factor receptors induced by proteolysis-targeting chimeras
Several epidermal growth factor receptor (EGFR) proteolysis-targeting chimeras
(PROTACs), including MS39 and MS154 developed by us, have been reported to effectively …
(PROTACs), including MS39 and MS154 developed by us, have been reported to effectively …
Targeting micro-environmental pathways by PROTACs as a therapeutic strategy
J Liu, Y Peng, H Inuzuka, W Wei - Seminars in cancer biology, 2022 - Elsevier
Tumor microenvironment (TME) composes of multiple cell types and non-cellular
components, which supports the proliferation, metastasis and immune surveillance evasion …
components, which supports the proliferation, metastasis and immune surveillance evasion …
[HTML][HTML] The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region
G Fan, F Wang, Y Chen, Q Zheng, J Xiong, Q Lv, K Wu… - Cell Reports, 2023 - cell.com
Akt is commonly activated and serves as a valuable target in human cancer. In this study,
OTUD1 is identified as an Akt-associated protein and is downregulated upon Akt activation …
OTUD1 is identified as an Akt-associated protein and is downregulated upon Akt activation …