Targeting the cancer epigenome for therapy
Next-generation sequencing has revealed that more than 50% of human cancers harbour
mutations in enzymes that are involved in chromatin organization. Tumour cells not only are …
mutations in enzymes that are involved in chromatin organization. Tumour cells not only are …
Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit
SL McGee, M Hargreaves - Nature Reviews Endocrinology, 2020 - nature.com
Exercise is fundamental for good health, whereas physical inactivity underpins many chronic
diseases of modern society. It is well appreciated that regular exercise improves metabolism …
diseases of modern society. It is well appreciated that regular exercise improves metabolism …
Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation
S Kaluscha, S Domcke, C Wirbelauer, MB Stadler… - Nature …, 2022 - nature.com
Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …
Basset: learning the regulatory code of the accessible genome with deep convolutional neural networks
The complex language of eukaryotic gene expression remains incompletely understood.
Despite the importance suggested by many noncoding variants statistically associated with …
Despite the importance suggested by many noncoding variants statistically associated with …
Transcription factors as readers and effectors of DNA methylation
Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …
base-pair resolution under various physiological conditions. Many aberrant or differentially …
Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions
S Morita, H Noguchi, T Horii, K Nakabayashi… - Nature …, 2016 - nature.com
Despite the importance of DNA methylation in health and disease, technologies to readily
manipulate methylation of specific sequences for functional analysis and therapeutic …
manipulate methylation of specific sequences for functional analysis and therapeutic …
DNA methylation in mammals
E Li, Y Zhang - Cold Spring Harbor perspectives in …, 2014 - cshperspectives.cshlp.org
DNA methylation is one of the best characterized epigenetic modifications. In mammals it is
involved in various biological processes including the silencing of transposable elements …
involved in various biological processes including the silencing of transposable elements …
[HTML][HTML] A CRISPR–dCas toolbox for genetic engineering and synthetic biology
Programmable control of gene expression is essential to understanding gene function,
engineering cellular behaviors, and developing therapeutics. Beyond the gene editing …
engineering cellular behaviors, and developing therapeutics. Beyond the gene editing …
[HTML][HTML] Sperm epigenetics and influence of environmental factors
Background Developmental programming of the embryo is controlled by genetic information
but also dictated by epigenetic information contained in spermatozoa. Lifestyle and …
but also dictated by epigenetic information contained in spermatozoa. Lifestyle and …
methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles
DNA methylation is a chemical modification of cytosine bases that is pivotal for gene
regulation, cellular specification and cancer development. Here, we describe an R package …
regulation, cellular specification and cancer development. Here, we describe an R package …