Methyltransferase-like proteins in cancer biology and potential therapeutic targeting

YN Qi, Z Liu, LL Hong, P Li, ZQ Ling - Journal of Hematology & Oncology, 2023 - Springer
RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …

[HTML][HTML] The emerging importance role of m6A modification in liver disease

S Wang, S Gao, W Ye, Y Li, J Luan, X Lv - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Abstract N6-methyladenosine (m6A) modification, as one of the most common types of inner
RNA modification in eukaryotes, plays a multifunctional role in normal and abnormal …

Short-chain fatty acid-butyric acid ameliorates granulosa cells inflammation through regulating METTL3-mediated N6-methyladenosine modification of FOSL2 in …

K Liu, X He, J Huang, S Yu, M Cui, M Gao, L Liu… - Clinical …, 2023 - Springer
Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder characterized by
chronic low-grade inflammation. Previous studies have demonstrated that the gut …

DNA 5mC and RNA m6A modification successively facilitates the initiation and perpetuation stages of HSC activation in liver fibrosis progression

Y Feng, S Guo, Y Zhao, H Dong, J Qian, Y Hu… - Cell Death & …, 2023 - nature.com
Hepatic stellate cells (HSC) are key effector cells in liver fibrosis. Upon stimulation, the
quiescent HSC undergoes complex morphological and functional changes to …

Changes in m6A in steatotic liver disease

BJ Petri, MC Cave, CM Klinge - Genes, 2023 - mdpi.com
Fatty liver disease is one of the major causes of morbidity and mortality worldwide. Fatty liver
includes non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis …

N6-methyladenosine in macrophage function: a novel target for metabolic diseases

X Zhu, HJ Tang, M Yang, K Yin - Trends in Endocrinology & Metabolism, 2023 - cell.com
Abstract N6-methyladenosine (m 6 A) is one of the most prevalent internal transcriptional
modifications. Evidence has highlighted changes in m 6 A in metabolic disorders and …

N6-methyladenosine RNA methylation in liver diseases: from mechanism to treatment

L Yang, S Tian, X Zheng, M Zhang, X Zhou… - Journal of …, 2023 - Springer
Epigenetic modification occurring in RNA has become the hotspot of the field. N 6-
methyladenosine (m6A) methylation is the most abundant RNA internal modification mainly …

[HTML][HTML] Epigenetic modification in liver fibrosis: Promising therapeutic direction with significant challenges ahead

R Liu, Y Li, Q Zheng, M Ding, H Zhou, X Li - Acta Pharmaceutica Sinica B, 2024 - Elsevier
Liver fibrosis, characterized by scar tissue formation, can ultimately result in liver failure. It's a
major cause of morbidity and mortality globally, often associated with chronic liver diseases …

METTL3-mediated m6A mRNA modification was involved in cadmium-induced liver injury

W Li, M Tan, H Wang, Z Wang, Y Pang, R Yang… - Environmental …, 2023 - Elsevier
Cadmium is an environmental pollutant that has extensive deleterious effects. However, the
mechanisms underlying the hepatotoxicity induced by long-term exposure to cadmium …

N6-methyladenosine enhances the expression of TGF-β-SMAD signaling family to inhibit cell growth and promote cell metastasis

B Peng, S Cheng, H Wang, T Liu, Y Gu, L Duan… - Cancer Letters, 2024 - Elsevier
TGF-β-SMAD signaling pathway plays an important role in the progression of various
cancers. However, posttranscriptional regulation such as N 6-methyladenosine (m 6 A) of …