Migraine is a disabling neurological disorder, diagnosis of which is based on clinical criteria.
A shortcoming of these criteria is that they do not fully capture the heterogeneity of migraine …

Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

The midcycle surge of LH sets in motion interconnected networks of signaling cascades to
bring about rupture of the follicle and release of the oocyte during ovulation. Many mediators …

The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …

The etiology of migraine pain involves sensitized meningeal afferents that densely innervate
the dural vasculature. These afferents, with their cell bodies located in the trigeminal …

Migraine is a collection of perplexing neurological conditions in which the brain and its
associated tissues have been implicated as major players during an attack. Once …

Migraine is a common and complex brain disorder. Although it is clear that head pain is a
key manifestation of the disorder for most patients, what drives the activation of neuronal …

Migraine is a complex disorder characterized by recurrent episodes of headache, and is one
of the most prevalent and disabling neurological disorders. A key feature of migraine is that …

Chronic migraine is a disabling neurological disorder that imposes a considerable burden
on individual and socioeconomic outcomes. Chronic migraine is defined as headaches …

Background Migraine is a disabling and chronic neurovascular headache disorder.
Trigeminal vascular activation and release of calcitonin gene-related peptide (CGRP) play a …