Blood–brain barrier (BBB) strictly controls matter exchange between blood and brain, and
severely limits brain penetration of systemically administered drugs, resulting in ineffective …

Nanoparticles are zero-dimensional nanomaterials and, based on their nature, they can be
categorized into organic, inorganic, and composites nanoparticles. Due to their unique …

Ischemic stroke is a cerebrovascular disease normally caused by interrupted blood supply to
the brain. Ischemia would initiate the cascade reaction consisted of multiple biochemical …

Small interfering RNA (siRNA)-based gene silencing technology has demonstrated
significant potential for treating brain-associated diseases. However, effective and safe …

Cell membrane coating has recently emerged as a promising biomimetic approach to
engineering nanoparticles (NPs) for targeted drug delivery. However, simple cell membrane …

In recent years, nanomedicines have emerged as a promising method for central nervous
system drug delivery, enabling the drugs to overcome the blood-brain barrier and …

Ischemic stroke is a vascular central nervous system (CNS) disease that leads a disability
and death. Thrombolysis and neuroprotection are the primary treatment strategies of …

The delivery of therapeutic molecules to the brain remains an unsolved problem to the
researchers due to the existence of the blood–brain barrier (BBB), which halts the entry of …

Neuroinflammation, an inflammatory response within the central nervous system (CNS), is a
main hallmark of common neurodegenerative diseases, including Alzheimer's disease (AD) …

Ischemic stroke is still a serious threat to human life and health, but there are few therapeutic
options available to treat stroke because of limited blood-brain penetration. The …