Copper dyshomeostasis in neurodegenerative diseases—therapeutic implications

G Gromadzka, B Tarnacka, A Flaga… - International journal of …, 2020 - mdpi.com
Copper is one of the most abundant basic transition metals in the human body. It takes part
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …

Metal toxicity links to Alzheimer's disease and neuroinflammation

TJ Huat, J Camats-Perna, EA Newcombe… - Journal of molecular …, 2019 - Elsevier
As the median age of the population increases, the number of individuals with Alzheimer's
disease (AD) and the associated socio-economic burden are predicted to worsen. While …

The toxicology of mercury: Current research and emerging trends

G Bjørklund, M Dadar, J Mutter, J Aaseth - Environmental research, 2017 - Elsevier
Mercury (Hg) is a persistent bio-accumulative toxic metal with unique physicochemical
properties of public health concern since their natural and anthropogenic diffusions still …

[HTML][HTML] Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer's disease: Limitations, and current and future perspectives

KD Fasae, AO Abolaji, TR Faloye, AY Odunsi… - Journal of Trace …, 2021 - Elsevier
Background Alzheimer's disease (AD) is the most prevalent cause of cognitive impairment
and dementia worldwide. The pathobiology of the disease has been studied in the form of …

Zinc complexes with nitrogen donor ligands as anticancer agents

M Porchia, M Pellei, F Del Bello, C Santini - Molecules, 2020 - mdpi.com
The search for anticancer metal-based drugs alternative to platinum derivatives could not
exclude zinc derivatives due to the importance of this metal for the correct functioning of the …

Link between aluminum and the pathogenesis of Alzheimer′ s disease: the integration of the aluminum and amyloid cascade hypotheses

M Kawahara, M Kato-Negishi - International journal of …, 2011 - Wiley Online Library
Whilst being environmentally abundant, aluminum is not essential for life. On the contrary,
aluminum is a widely recognized neurotoxin that inhibits more than 200 biologically …

Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease

K Rajasekhar, M Chakrabarti… - Chemical …, 2015 - pubs.rsc.org
Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …

Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6

J Yang, P Minkler, D Grove, R Wang, B Willard… - Communications …, 2019 - nature.com
Hydrogen sulfide (H2S) plays important roles in metabolism and health. Its enzymatic
generation from sulfur-containing amino acids (SAAs) is well characterized. However, the …

Copper toxicity links to pathogenesis of Alzheimer's disease and therapeutics approaches

HW Ejaz, W Wang, M Lang - International Journal of Molecular Sciences, 2020 - mdpi.com
Alzheimer's disease (AD) is an irreversible, age-related progressive neurological disorder,
and the most common type of dementia in aged people. Neuropathological lesions of AD …

Polyphenols as potential metal chelation compounds against Alzheimer's disease

J Lakey-Beitia, AM Burillo, G La Penna… - Journal of …, 2021 - content.iospress.com
Alzheimer's disease (AD) is the most common neurodegenerative disease affecting more
than 50 million people worldwide. The pathology of this multifactorial disease is primarily …