Copper dyshomeostasis in neurodegenerative diseases—therapeutic implications
G Gromadzka, B Tarnacka, A Flaga… - International journal of …, 2020 - mdpi.com
Copper is one of the most abundant basic transition metals in the human body. It takes part
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …
Metal toxicity links to Alzheimer's disease and neuroinflammation
As the median age of the population increases, the number of individuals with Alzheimer's
disease (AD) and the associated socio-economic burden are predicted to worsen. While …
disease (AD) and the associated socio-economic burden are predicted to worsen. While …
The toxicology of mercury: Current research and emerging trends
G Bjørklund, M Dadar, J Mutter, J Aaseth - Environmental research, 2017 - Elsevier
Mercury (Hg) is a persistent bio-accumulative toxic metal with unique physicochemical
properties of public health concern since their natural and anthropogenic diffusions still …
properties of public health concern since their natural and anthropogenic diffusions still …
[HTML][HTML] Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer's disease: Limitations, and current and future perspectives
Background Alzheimer's disease (AD) is the most prevalent cause of cognitive impairment
and dementia worldwide. The pathobiology of the disease has been studied in the form of …
and dementia worldwide. The pathobiology of the disease has been studied in the form of …
Zinc complexes with nitrogen donor ligands as anticancer agents
The search for anticancer metal-based drugs alternative to platinum derivatives could not
exclude zinc derivatives due to the importance of this metal for the correct functioning of the …
exclude zinc derivatives due to the importance of this metal for the correct functioning of the …
Link between aluminum and the pathogenesis of Alzheimer′ s disease: the integration of the aluminum and amyloid cascade hypotheses
M Kawahara, M Kato-Negishi - International journal of …, 2011 - Wiley Online Library
Whilst being environmentally abundant, aluminum is not essential for life. On the contrary,
aluminum is a widely recognized neurotoxin that inhibits more than 200 biologically …
aluminum is a widely recognized neurotoxin that inhibits more than 200 biologically …
Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease
K Rajasekhar, M Chakrabarti… - Chemical …, 2015 - pubs.rsc.org
Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …
Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6
Hydrogen sulfide (H2S) plays important roles in metabolism and health. Its enzymatic
generation from sulfur-containing amino acids (SAAs) is well characterized. However, the …
generation from sulfur-containing amino acids (SAAs) is well characterized. However, the …
Copper toxicity links to pathogenesis of Alzheimer's disease and therapeutics approaches
HW Ejaz, W Wang, M Lang - International Journal of Molecular Sciences, 2020 - mdpi.com
Alzheimer's disease (AD) is an irreversible, age-related progressive neurological disorder,
and the most common type of dementia in aged people. Neuropathological lesions of AD …
and the most common type of dementia in aged people. Neuropathological lesions of AD …
Polyphenols as potential metal chelation compounds against Alzheimer's disease
J Lakey-Beitia, AM Burillo, G La Penna… - Journal of …, 2021 - content.iospress.com
Alzheimer's disease (AD) is the most common neurodegenerative disease affecting more
than 50 million people worldwide. The pathology of this multifactorial disease is primarily …
than 50 million people worldwide. The pathology of this multifactorial disease is primarily …