Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or
lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key …

The past two years have seen an explosion in the structural understanding of the endosomal
sorting complex required for transport (ESCRT) machinery that facilitates the trafficking of …

The identification of key genes in transcriptomic data constitutes a huge challenge. Our
review of microarray reports revealed 88 genes whose transcription is consistently regulated …

A necessary step in the genesis of an extracellular enveloped virus particle is the formation
of an outer virion membrane. Often, virion membrane is derived from host cell membranes …

The human immunodeficiency virus (HIV) type-1 viral protein U (Vpu) protein enhances the
release of diverse retroviruses from human, but not monkey, cells and is thought to do so by …

The plasma membrane is the final barrier that enveloped viruses must cross during their
egress from the infected cell. Here, we review recent insights into the cell biology of retroviral …

ESCRT complexes form the main machinery driving protein sorting from endosomes to
lysosomes. Currently, the picture regarding assembly of ESCRTs on endosomes is …

Retroviruses make a long and complex journey from outside the cell to the nucleus in the
early stages of infection, and then an equally long journey back out again in the late stages …

The endosomal sorting complex required for transport-I (ESCRT-I) complex, which is
conserved from yeast to humans, directs the lysosomal degradation of ubiquitinated …

The three endosomal sorting complexes required for transport (ESCRTs) are integral to the
degradation of endocytosed membrane proteins and multivesicular body (MVB) biogenesis …