The endoplasmic reticulum is the most abundant membrane organelle in eukaryotic cells. It
is an important site of membrane and secretory protein folding and glycolipid synthesis and …

Sleep disturbances are an emerging risk factor for metabolic diseases, for which the burden
is particularly worrying worldwide. The importance of sleep for metabolic health is being …

Scope Hepatic steatosis is a major health issue that can be attenuated by a healthy diet.
This study investigates the effects and molecular mechanisms of butyrate, a dietary fiber …

Background: Aging and sedentary behavior are independent risk factors for non-
communicable diseases. An active lifestyle and structured physical activity are positively …

The article discusses the significant impact of regular physical activity/exercise (PA/PE) on
health, disease prevention, and its potential role in enhancing resilience. It emphasizes the …

Diabetic neuropathic pain (DNP) is a frequent complication of diabetes. Calcium/calmodulin-
dependent protein kinase II α (CaMKIIα), a multi-functional serine/threonine kinase subunit …

Melatonin acute treatment limits obesity of young Zücker diabetic fatty (ZDF) rats by non-
shivering thermogenesis (NST). We recently showed melatonin chronically increases the …

Metabolic syndrome (MetS) is characterized by insulin resistance, hyperglycemia, excessive
fat accumulation and dyslipidemia, and is known to be accompanied by neuropathological …

The calcium/calmodulin-dependent protein kinase II (CaMKII) is a mediator of calcium
signals and regulates fatty acid metabolism in mammalian cells. Cmk2p is a yeast homolog …

Liver transthyretin (TTR) synthesis and release are exacerbated in insulin-resistant states
but are decreased by exercise training, in relation to the insulin-sensitizing effects of …