Mechanisms of muscle atrophy and hypertrophy: implications in health and disease

R Sartori, V Romanello, M Sandri - Nature communications, 2021 - nature.com
Skeletal muscle is the protein reservoir of our body and an important regulator of glucose
and lipid homeostasis. Consequently, the growth or the loss of muscle mass can influence …

Skeletal muscle atrophy: From mechanisms to treatments

L Yin, N Li, W Jia, N Wang, M Liang, X Yang… - Pharmacological …, 2021 - Elsevier
Skeletal muscle is a crucial tissue for movement, gestural assistance, metabolic
homeostasis, and thermogenesis. It makes up approximately 40% of the total body weight …

The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia

L Sylow, VL Tokarz, EA Richter, A Klip - Cell Metabolism, 2021 - cell.com
As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells

J Yang, M Vamvini, P Nigro, LL Ho, K Galani, M Alvarez… - Cell metabolism, 2022 - cell.com
Exercise training is critical for the prevention and treatment of obesity, but its underlying
mechanisms remain incompletely understood given the challenge of profiling …

Key genes regulating skeletal muscle development and growth in farm animals

M Mohammadabadi, F Bordbar, J Jensen, M Du… - Animals, 2021 - mdpi.com
Simple Summary Skeletal muscle mass is an important economic trait, and muscle
development and growth is a crucial factor to supply enough meat for human consumption …

Signaling pathways that control muscle mass

A Vainshtein, M Sandri - International journal of molecular sciences, 2020 - mdpi.com
The loss of skeletal muscle mass under a wide range of acute and chronic maladies is
associated with poor prognosis, reduced quality of life, and increased mortality. Decades of …

[HTML][HTML] Receptor binding competition: A paradigm for regulating TGF-β family action

E Martinez-Hackert, A Sundan, T Holien - Cytokine & growth factor reviews, 2021 - Elsevier
The transforming growth factor (TGF)-β family is a group of structurally related,
multifunctional growth factors, or ligands that are crucially involved in the development …

Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease

JL Chen, KL Walton, A Hagg… - Proceedings of the …, 2017 - National Acad Sciences
The transforming growth factor-β (TGF-β) network of ligands and intracellular signaling
proteins is a subject of intense interest within the field of skeletal muscle biology. To define …

Muscle aging and sarcopenia: The pathology, etiology, and most promising therapeutic targets

M Grima-Terrén, S Campanario… - Molecular Aspects of …, 2024 - Elsevier
Sarcopenia is a progressive muscle wasting disorder that severely impacts the quality of life
of elderly individuals. Although the natural aging process primarily causes sarcopenia, it can …

A critical discussion on the relationship between E3 ubiquitin ligases, protein degradation, and skeletal muscle wasting: it's not that simple

DC Hughes, CA Goodman, LM Baehr… - … of Physiology-Cell …, 2023 - journals.physiology.org
Ubiquitination is an important post-translational modification (PTM) for protein substrates,
whereby ubiquitin is added to proteins through the coordinated activity of activating (E1) …