The pancreas is an essential organ for proper nutrient metabolism and has both endocrine
and exocrine function. In the past two decades, knowledge of how the pancreas develops …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …

The pancreas is an essential endoderm-derived organ that ensures nutrient metabolism via
its endocrine and exocrine functions. Here we review the essential processes governing the …

Introduction During radiotherapy salivary glands of head and neck cancer patients are
unavoidably co-irradiated, potentially resulting in life-long impairment. Recently we showed …

Objectives The aim of this study was to provide a comprehensive overview of the clinically
relevant anatomical and histological aspects of the development of the human pancreas …

In the developing embryo, appropriate patterning of the endoderm fated to become
pancreas requires the spatial and temporal coordination of soluble factors secreted by the …

Blood vessels course through organs, providing them with essential nutrient and gaseous
exchange. However, the vasculature has also been shown to provide non-nutritional signals …

Pancreatic islets are highly vascularized mini-organs, and vascular endothelial growth factor
(VEGF)-A is a critical factor in the development of islet vascularization. To investigate the …

In vitro derivation of pancreatic β-cells from human pluripotent stem cells holds promise as
diabetes treatment. Despite recent progress, efforts to generate physiologically competent β …