Selective autophagy is the lysosomal degradation of specific intracellular components
sequestered into autophagosomes, late endosomes, or lysosomes through the activity of …

Macrophages are first-line responders against microbes. The success of Mycobacterium
tuberculosis (Mtb) rests upon its ability to convert these antimicrobial cells into a permissive …

Macroautophagy/autophagy, a defense mechanism against aberrant stresses, in neurons
counteracts aggregate-prone misfolded protein toxicity. Autophagy induction might be …

Lysosomes are the terminal degradative compartment of autophagy, endocytosis and
phagocytosis. What once was viewed as a simple acidic organelle in charge of …

Galectins are animal lectins with specific affinity for galactosides via the conserved
carbohydrate recognition domains. Increasing studies recently have identified critical roles …

Autophagy is an evolutionarily conserved cellular pathway that culminates in lysosomal
degradation of selected substrates. Autophagy can serve dual roles in virus infection with …

The tripartite-motif (TRIM) family represents one of the largest classes of putative single
protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular …

Sequestration of protein aggregates in inclusion bodies and their subsequent degradation
prevents proteostasis imbalance, cytotoxicity, and proteinopathies. The underlying …

As a member of the TRIM (tripartite motif) protein family, TRIM56 can function as an E3
ubiquitin ligase. In addition, TRIM56 has been shown to possess deubiquitinase activity and …

Lysosomes are central organelles for cellular degradation and energy homeostasis. In
addition, lysosomal membrane permeabilization (LMP) and subsequent release of …