Membranes are essential for life. They act as semi-permeable boundaries that define cells
and organelles. In addition, their surfaces actively participate in biochemical reaction …

Phosphoinositides broadly impact membrane dynamics, signal transduction and cellular
physiology. The orchestration of signaling complexity by this seemingly simple metabolic …

Abstract The phosphatidylinositol 4-phosphate 5-kinase (PIP5K) family of lipid-modifying
enzymes generate the majority of phosphatidylinositol 4, 5-bisphosphate [PI (4, 5) P 2] lipids …

Ras is a small GTPase that is central to important functional decisions in diverse cell types.
An important aspect of Ras signaling is its ability to exhibit bimodal or switch-like activity. We …

The aim of this study was to examine, in biochemical detail, the functional role of the Arg152
residue in the selenoprotein Glutathione Peroxidase 4 (GPX4), whose mutation to His is …

We reconstitute a phosphotyrosine-mediated protein condensation phase transition of the∼
200 residue cytoplasmic tail of the epidermal growth factor receptor (EGFR) and the adaptor …

Signaling through the Ras-MAPK pathway can exhibit switch-like activation, which has been
attributed to the underlying positive feedback and bimodality in the activation of RasGDP to …

The lack of knowledge about adsorption characteristics limits the acquisition of
phospholipase D (PLD) selectivity information for various phospholipids. In this study, we …

The oncogene PI3Kα and the tumor suppressor PTEN represent two antagonistic enzymatic
activities that regulate the interconversion of the phosphoinositide lipids PI (4, 5) P 2 and PI …

Blood coagulation is a network of biochemical reactions wherein dozens of proteins act
collectively to initiate a rapid clotting response. Coagulation reactions are lipid-surface …